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October-December 1969
Volume 1 | Issue 4
Page Nos. 1-52
Accessed 12,290 times.
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| REVIEW ARTICLE |
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Preclinical safety evaluation of new drugs |
p. 1 |
| RR Rao |
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| RESEARCH PAPER |
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Effect of reserpine pretreatment on barbiturate sleeping time and brain barbiturate concentration in rats |
p. 14 |
| H Vimala, Sethy, SR Naik, UK Sheth |
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Studies on a potential anti-ulcer compound b-N-di-n propyl aminoethyl-o-methoxoy phenylether hydrochloride |
p. 19 |
| GB Singh, NM Khanna, AP Bhaduri |
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A comparison of the experimental methods for screening of anti-inflammatory activity |
p. 24 |
| MB Gupta, KK Tabgrum, GP Gupta, KP Bhargava |
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Central antiserotonin activity of certain antihistaminics |
p. 32 |
| SK Bapat, Chandra Vimal
The central 5-HT antagonist activity of 5 newer antihistaminics (chlorprothixene, chlorpentixol, diphenylpyraline, cyproheptadine, and mebhydrolin) has been studied and all of them have been found to possess central anti - 5-HT activity. These drugs have also been screened by the metrazol threshold test and all the five have been found to increase the toxicity of metrazol. A possible correlation between potentiation of metrazol toxicity and central anti-5-HT activity of these drugs has been discussed. It has been suggested that these drugs should be avoided or be given with caution while treating the patients of petit mal epilepsy for allergic manifestations.
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| RESEARCH PAPER |
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Synthesis of quinazolone arylalkyl hydrazines: role of quinazolone ring substitution on the monoamine oxidase inhibitory activity |
p. 37 |
| SS Parmar, RC Arora, JP Barthwal |
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| RESEARCH PAPER |
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Interaction of morphine and dopamine on some smooth muscles |
p. 50 |
| JN Sharma, BN Dhawan, KN Dhawan |
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