1. (Propranolol in doses of 1 and 3 mg/kg facilitated whereas 10 and 30 mg/kg inhibited footshock aggression (FSA) in rats. 2. Atropine but not atropine methylnitrate antagonised the antiaggressive effect of (() propranolol (IO mg/kg) wlthout affecting the facilitatory affect on FSA. 3. Racemic propranolol (1 and 10 mg/kg) also antagonised reserpine apomorphine aggression. 4. It is suggested that central cholinergic as well as dopaminergic mechanisms could be involved in the anti-aggressive effect of propranolol.

1. Cimetidine (20 mg/kg/i.p) inhibited the peptic ulcer-index in histamine treated adult albino rats and afforded a protection of 22% and 23% respectively in hydrocortisone (7.5 mg/kg/i.p) and phenylbutazone (1.5 mg/kg/i.p) pretreated and similarly challenged animals. 2. Hydrocortisone and phenylbutazone in the aforementioned doses significantly inhibited the dextran/carrageenin induced oedema and cotton pellet granuloma. 3. Concurrent use of cimetidine did not significantly affect the antiinflammatory potential of phenylbutazone or hydrocortisone nor did it on its own modify any of the tested phase of inflammation.

1. Cimetidine (37.5 (g/kg) and disodium cromoglycate (20(g/kg) in combination produced 80.33% and 81.68% inhibition of free and total acidity respectively in rabbits from control value (P < 0.01). 2. Aspirin induced ulcers in rats were inhibited by prior administration of cimetidine or disodium cromoglycate. However, when the latter drugs were used in combination, the ulcer protection effect was significantly enhanced.

1. Tinospora cardifolia Miers is reputed to possess beneficial effects in liver ailments in Ayurvedic medicine. 2. Aqueous suspension of alcoholic extract was subjected to pharmacological investigations for hepatoprotective activity. 3. The extract did not effect the hexobarbitone and pentobarbitone induced sleeping time in normal rats and mice 4. In carbon tetrachloriie induced hepatic injury in rats it maintained the hexobarbitone induced sleeping time, serum glutamic oxaxacetic transaminase, glutamic pyruvic transaminase and alkaline phosphatase levels equivalent to the control values and protected the hepatic architecture. 5. It also significantly reduced bromsulphthalein clearance time in carbon tetrachloride treated rabbits and increased bile flow in rats.

1. Investigation of the biological activity of rhizomes indicate that they possess anti-inflammatory and analgesic activity. 2. The anti-inflammatory activity was localised mainly in the hexane fraction from which one of the pure active constituents, hedychenone has been isolated. The analgesic activity was more prominent in the benzene fraction. 3. Some other minor active constituents are also present which may contribute to the total activity of the rhizomes.

1. The central effect of aqueous and alcoholic extracts of the leaves of Lycopersicon esculentum (tomato) were studied. 2. The extracts exhibited central depressant activity and analgesic activity and blocked conditioned avoidance response. 3. It appears that the active principles responsible for central effects are other than tomatine. 4. The alcoholic extract produced a higher modality of central depression than the aqueous .extract.

1. The biochemical and haematological effects of tolmetin (a pyrole acetic acid derivative), on blood sugar,' serum cholesterol, serum uric acid, blood count, coagulation time, plasma fibrinogen content and euglobin clot lysis time (ELT) were studied in albino rabbits 2. Tolmetin (10 mg/kg), (P.O.) produced marked and significant hypoglycaemic, hypocholesterolaemic and hypouricaemic effects which started after one hour with a peak effect at two hours without complete recovery even upto four hours. 3. It decreased coagulation time and platelet count but increased plasma fibrinogen level and ELT.

1. The effect of alloxan, a sugar cataractogenic substance on glutathione (GSH) and glutathione reductase (GSH-R) activity in blood, aqueous humor and lenses of normal and treated rats is reported. 2.In contrast to normal lenses, alloxan induced cataractous lenses showed an i ncrease in CSH-R activity and fall in CSH content in blood, aqueous humor and Iens indicating that alloxan may interfere with intracellular oxidation reduction process in the lens and thus lead to cataract formation.

1. The analgesic activity of alcoholic extract of whole plant of cissus quadrangularis family vitaceae), was studied in mice by Haffner's Clip and Eddy's hot plate methods. 2. The extract effective by both oral and i.p. routes significantly (P < 0.001) increased the reaction time by both methods. 3. The duration of analgesic activity was from 2 to 4 h and optimum effect was observed at l/20th -1/10th of LD50 dose. The extract compared well with acetylsalicylic acid.