A series of Mannich condensation products containing the (-( 1-adamantylamino) propiophenone skeleton (Type I) and the O-(1 -ademantylaminomethyI) phenol (Type II) were tested for possible antiparkinson activity. Compound 3 had a significant anticatatonic effect and lacked anticholinergic activity. Both of these findings were comparable to amantadine hydrochloride.

The effect of different adrenergic blockers on pulmonary edema induced by trauma to skull have been studied in mice. Propranolol (beta blocker) prevented pulmonary edema induced by trauma to skull whereas tolazoline (alpha blocker) as well as guanathedine (adrenergic neuron blocker) did not prevent pulmonary edema. Since propanolol is not having the property to prevent the increase of pulmonary capillary pressure induced by sympatho-adrenal storm due to trauma to skull. possibly It might have prevented the Pulmonary edema by blocking the primary increase of capillary permeability.

Reserpine induced emesis which has been ascribed to increased parasympathetic tone, remained uninhibited by drugs like atropine. haloperidol and pimozide. Chlorpromazine failed to block this emesis suggesting that reserpine did not act by stimulating the rudimentary chemoreceptor trigger zone in pigeons. Apomorphine failed to induce emesis in these birds. Cyclizine in low doses blocked the emetic response. although in higher doses it itself induced such an emetic response and also potentiated this response due to reserpine. Bilateral vagotomy at the carotid level failed to block the emesis. Histological studies indicate desquamation of epithelial cells induced by reserpine. Reserpine induced emesis appears to be mediated by dopaminergic, serotonergic and hormonal factors.

The concentration of diethylcarbamazine citrate in the blood of bull-calves reached the peak level (1.46 ( 0.24 mg/100 ml) within 10 min after an intramuscular dose of 50 mg/kg. The blood levels gradually receded to 0.94 ( 0.20, 0.24 ( 0.06, 0.31 ( O.17. 0.28 ( O.18 and 0.26 ( 0.12 mg/100 ml at 1, 3, 6, 9, and 12 hr post-injection and completely disappeared from circulation at 22 hr. The urinary excretion of diethycarbamazine started within 3 hr of injection. The excretion rate was 0.85 ( 0.12, 1.5 ( 0.18, 1.2 ( 0.17, 0.48(0.14, 0.29 ( 0.24 and 0.27 ( 0.23 mg/ml during 3.9, 16.22. 33 and 48 hr respectively. From about 6 day onwards the urinary excretion tapered out to zero in course of 63-70 days.

Amino acids, L-valine, L-threonine. L-alanine, L-leucine and L-aspartic acid. were tested for their action on the primary and secondary immune response induced by typhoid 'H' antigen in rabbits. Antibody titres were determined using Widal's tube agglutination technique at different levels of antibody formation. All the amino acids excepting L-leucine significantly depressed the primary immune response. Secondary immune response was depressed only by L-alanine. Study of serum protein fractions by electrophoretic technique revealed no significant differences in the gamma globulin levels in control and drug-treated groups.

Intracerebroventricular injection of adrenaline. nor-adrenaline, 5-hydroxytryptamine (5-HT). histamine and prostaglandin-E1 (POE1) through a chronically implanted cannula was observed on the rectal temperature of guinea pigs. Adrenaline, nor-adrenaline, 5-HT and histamine produced a fall whereas PGE2 produced a rise in temperature.

The action of oxytocin has been investigated on the perfused blood vessels of rat hind-limb and rat mesentary. The vaso-constrictor action of oxytocin on these two isolated preparations remained unaffected by alpha and beta adrenergic receptor blocking drugs and antihistamines. Tissues obtained from rats, either reserpinized or primed with oestrogen. exhibited more pronounced constrictor action on the two preparations. The probable mode of constrictor action of oxytocin is discussed.

Effect of alcohol on blood glucose level was observed after obtaining similar plasma ethanol concentrations in normal as well as starved rabbits. No alteration in blood glucose level as well as in liver glycogen content was observed in normal rabbits. However, the starved animals revealed a marked fall in blood glucose level accompained by depleted liver glycogen stores. Thus we observe that ethanol is capable of producing hypoglycemia in the animals with exhausted hepatic glycogen stores, irrespective of the amount administered to them.

The effects of non-steroidal anti-inflammatory drugs sodium salicylate. phenylbutaonze. Indomethacin and ibuprofen have bean investigated against prostaglandin E1-induced inflammation in rat hind-paw. Sodium salicylate and ibuprofen significantly inhibit the inflammation which appears to be a result of direct antagonism of prostaglandin.