Acute oral toxicity studies on sumithion, an organophosphorus insecticide in mice were conducted. The symptoms exhibited by the mice were characteristic of toxicity of anricholinesterase agents. The oral LD50 was found to be 884 mglkg body weight. The effect of LD50 on cholinesterase activity in blood and brain was also studied. The toxic symptoms appeared after about I5 to 30 min. The maximum cholinesterase. inhibition in both blood and brain (74% and 86% respectively) was noted after one hour of administration of the insecticide.

Twenty seven patients having raised intra cranial pressure of varied etiology like trauma, tuberculosis, neoplasms and non-haemorrhagic cerebrovascular accidents were treated with 10% glycerol intravenously. There was marked clinical improvement in twenty three cases. Intravenous administration of glycerol was non-toxic and the response was better than mannitol.