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Year : 2022  |  Volume : 54  |  Issue : 2  |  Page : 153-

Role of Vitamin D in COVID-19: Correspondence

Pathum Sookaromdee1, Viroj Wiwanitkit2,  
1 Private Academic Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India

Correspondence Address:
Dr. Pathum Sookaromdee
Private Academic Consultant, 11 Bangkok 112 Bangkok 103320

How to cite this article:
Sookaromdee P, Wiwanitkit V. Role of Vitamin D in COVID-19: Correspondence.Indian J Pharmacol 2022;54:153-153

How to cite this URL:
Sookaromdee P, Wiwanitkit V. Role of Vitamin D in COVID-19: Correspondence. Indian J Pharmacol [serial online] 2022 [cited 2022 Jun 30 ];54:153-153
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We would like to share ideas on “Evidences suggesting a possible role of Vitamin D in COVID 19: The missing link.”[1] Singh et al. concluded that “Using Vitamin D as prophylaxis and/or chemotherapeutic treatment … of Vitamin D affecting many people worldwide.”[1] We agree that Vitamin D might play a role in the management of COVID-19. Trials might be useful. Considering trial, some important concerns are hereby discussed. First, it should assess the impact of genetic polymorphism. Vitamin D-binding protein polymorphism might be associated with outcome of Vitamin D supplementation in the COVID-19 treatment.[2] Additionally, if a trial will be performed, a background Vitamin D data of subjects should be assessed.

The effect of Vitamin D in COVID-19 might also be associated with some other modifiers. Sunlight exposure and estrogen interaction should be discussed. Estradiol is also proposed for its usefulness in managing COVID-19.[3] There might be an interesting co-advantage of both Vitamin D and estradiol in the management of COVID-19.

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The authors ask for waiving for any charge for this correspondence.


1Singh S, Singh CM, Ranjan A, Kumar S, Singh DK. Evidences suggesting a possible role of Vitamin D in COVID 19: The missing link. Indian J Pharmacol 2021;53:394-402.
2Speeckaert MM, Delanghe JR. The potential significance of vitamin D binding protein polymorphism in COVID-19. Int J Infect Dis 2021;109:90.
3Youn JY, Zhang Y, Wu Y, Cannesson M, Cai H. Therapeutic application of estrogen for COVID-19: Attenuation of SARS-CoV-2 spike protein and IL-6 stimulated, ACE2-dependent NOX2 activation, ROS production and MCP-1 upregulation in endothelial cells. Redox Biol 2021;46:102099.