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LETTER TO THE EDITOR
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Year : 2022  |  Volume : 54  |  Issue : 2  |  Page : 153-

Role of Vitamin D in COVID-19: Correspondence

Pathum Sookaromdee1, Viroj Wiwanitkit2,  
1 Private Academic Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India

Correspondence Address:
Dr. Pathum Sookaromdee
Private Academic Consultant, 11 Bangkok 112 Bangkok 103320
Thailand




How to cite this article:
Sookaromdee P, Wiwanitkit V. Role of Vitamin D in COVID-19: Correspondence.Indian J Pharmacol 2022;54:153-153


How to cite this URL:
Sookaromdee P, Wiwanitkit V. Role of Vitamin D in COVID-19: Correspondence. Indian J Pharmacol [serial online] 2022 [cited 2022 Jun 30 ];54:153-153
Available from: https://www.ijp-online.com/text.asp?2022/54/2/153/344968


Full Text



Sir,

We would like to share ideas on “Evidences suggesting a possible role of Vitamin D in COVID 19: The missing link.”[1] Singh et al. concluded that “Using Vitamin D as prophylaxis and/or chemotherapeutic treatment … of Vitamin D affecting many people worldwide.”[1] We agree that Vitamin D might play a role in the management of COVID-19. Trials might be useful. Considering trial, some important concerns are hereby discussed. First, it should assess the impact of genetic polymorphism. Vitamin D-binding protein polymorphism might be associated with outcome of Vitamin D supplementation in the COVID-19 treatment.[2] Additionally, if a trial will be performed, a background Vitamin D data of subjects should be assessed.

The effect of Vitamin D in COVID-19 might also be associated with some other modifiers. Sunlight exposure and estrogen interaction should be discussed. Estradiol is also proposed for its usefulness in managing COVID-19.[3] There might be an interesting co-advantage of both Vitamin D and estradiol in the management of COVID-19.

Financial support and sponsorship

Nil.

Conflicts of interest

The authors ask for waiving for any charge for this correspondence.

References

1Singh S, Singh CM, Ranjan A, Kumar S, Singh DK. Evidences suggesting a possible role of Vitamin D in COVID 19: The missing link. Indian J Pharmacol 2021;53:394-402.
2Speeckaert MM, Delanghe JR. The potential significance of vitamin D binding protein polymorphism in COVID-19. Int J Infect Dis 2021;109:90.
3Youn JY, Zhang Y, Wu Y, Cannesson M, Cai H. Therapeutic application of estrogen for COVID-19: Attenuation of SARS-CoV-2 spike protein and IL-6 stimulated, ACE2-dependent NOX2 activation, ROS production and MCP-1 upregulation in endothelial cells. Redox Biol 2021;46:102099.