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Anabolic therapy with Equisetum arvense along with bone mineralising nutrients in ovariectomized rat model of osteoporosis
Swati D Kotwal, Smita R Badole
University Department of Biochemistry, RTM Nagpur University, Nagpur, Maharashtra, India
Correspondence Address:
Dr. Swati D Kotwal
University Department of Biochemistry, RTM Nagpur University, Nagpur, Maharashtra
India
Objective: Equisetum arvense has been used to treat bone diseases. The traditional supplementation of calcium and Vitamin D for osteoporosis patients is insufficient considering the rise in patients every year. We have observed that extending the calcium and Vitamin D supplement with L-lysine, L-proline, L-arginine, and L-ascorbic acid (N) positively affects bone mineralization in ovariectomized rat. Here, we report a further extension of the above supplement with E. arvense.
Materials and Methods: The changes in serum biomarkers, bone mineral content, and femur bone histology were studied and compared to the standard drug for osteoporosis, namely raloxifene (RAL).
Results: We report a significant change in formation and resorption markers of bone as well as in cortical bone thickness and trabecular width in N and N + EA groups. The treatment N + EA also restored lipid profile near to normal level compared to ovariectomized group.
Conclusions: Treatment N + EA was found to be as effective as RAL in reversing the osteoporotic changes.
How to cite this article:
Kotwal SD, Badole SR. Anabolic therapy with Equisetum arvense along with bone mineralising nutrients in ovariectomized rat model of osteoporosis.Indian J Pharmacol 2016;48:312-315
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How to cite this URL:
Kotwal SD, Badole SR. Anabolic therapy with Equisetum arvense along with bone mineralising nutrients in ovariectomized rat model of osteoporosis. Indian J Pharmacol [serial online] 2016 [cited 2023 Mar 24 ];48:312-315
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2016;volume=48;issue=3;spage=312;epage=315;aulast=Kotwal;type=0 |
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