The effects of tramadol on hepatic ischemia/reperfusion injury in rats
Mona F Mahmoud1, Samar Gamal1, Mohamed A Shaheen2, Hassan M El-Fayoumi2
1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
2 Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Objectives: Tramadol is a centrally acting synthetic analgesic. It has a cardioprotective effect against myocardial ischemia-reperfusion (I/R) injury in isolated rat heart. We hypothesized that tramadol may exert a similar protective effect on hepatic I/R injury. Hence, the current investigation was designed to study the possible protective effects of tramadol on experimentally-induced hepatic I/R injury in rats.
Materials and Methods: Tramadol was administered 30 min before ischemia following which the rats were subjected to 45 min of ischemia followed by 1 h of reperfusion.
Results: Tramadol attenuated hepatic injury induced by I/R as evidenced by the reduction of transaminases, structural changes, and apoptotic cell death. It decreased the level of inflammatory markers such as tumor necrosis factor-alpha (TNF-α), TNF-α/interleukin-10 (IL-10) ratio, and nuclear factor-κB gene expression. It also increased the anti-inflammatory cytokine, IL-10 levels in hepatic tissues. Furthermore, it reduced oxidative stress parameters except manganese superoxide dismutase activity.
Conclusion: The results suggest that tramadol has hepatoprotective effects against hepatic I/R injury via anti-inflammatory, antiapoptotic, and antioxidant effects.
Dr. Mona F Mahmoud
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig
|How to cite this article:|
Mahmoud MF, Gamal S, Shaheen MA, El-Fayoumi HM. The effects of tramadol on hepatic ischemia/reperfusion injury in rats.Indian J Pharmacol 2016;48:275-280
|How to cite this URL:|
Mahmoud MF, Gamal S, Shaheen MA, El-Fayoumi HM. The effects of tramadol on hepatic ischemia/reperfusion injury in rats. Indian J Pharmacol [serial online] 2016 [cited 2021 Oct 25 ];48:275-280
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2016;volume=48;issue=3;spage=275;epage=280;aulast=Mahmoud;type=0