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Year : 2016  |  Volume : 48  |  Issue : 2  |  Page : 196--199

The effect of 5-aminosalicylic acid on renal ischemia-reperfusion injury in rats

Shokofeh Banaei 
 Department of Physiology, Ardabil University of Medical Sciences, Ardabil, Iran

Correspondence Address:
Shokofeh Banaei
Department of Physiology, Ardabil University of Medical Sciences, Ardabil
Iran

Objectives: Ischemia-reperfusion (IR) contributes to the development acute renal failure. Oxygen free radicals are involved in the pathophysiology of IR injury (IRI). This study was designed to investigate the effects of 5-aminosalicylic acid (5-ASA), which is known antioxidant agent, in IR-induced renal injury in rats. Materials and Methods: Male Wistar albino rats were unilaterally nephrectomized and subjected to 45 min of renal pedicle occlusion followed by 24 h of reperfusion. 5-ASA (300 mg/kg, i.p) was administered prior to ischemia. After 24 h reperfusion, urine and blood samples were collected for the determination of creatinine (Cr) and nitric oxide (NO) levels, and renal samples were taken for the histological evaluation. Results: Treatment with 5-ASA significantly decreased serum Cr and NO levels, also significantly increased urinary Cr level and decreased histopathological changes induced by IR. Conclusion: Treatment with 5-ASA had a beneficial effect on renal IRI. These results may indicate that 5-ASA exerts nephroprotective effects in renal IRI.


How to cite this article:
Banaei S. The effect of 5-aminosalicylic acid on renal ischemia-reperfusion injury in rats.Indian J Pharmacol 2016;48:196-199


How to cite this URL:
Banaei S. The effect of 5-aminosalicylic acid on renal ischemia-reperfusion injury in rats. Indian J Pharmacol [serial online] 2016 [cited 2022 Dec 2 ];48:196-199
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2016;volume=48;issue=2;spage=196;epage=199;aulast=Banaei;type=0