Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain
Veysel Baskin1, S Sirri Bilge1, Ayhan Bozkurt2, Bahar Akyuz1, Arzu Erdal Agri1, Hasan Guzel1, Fatih Ilkaya1
1 Department of Pharmacology, Medical Faculty, University of Ondokuz Mayis, Samsun, Turkey
2 Department of Physiology, Medical Faculty, University of Ondokuz Mayis, Samsun, Turkey
Objectives: To investigate nonsteroidal anti-inflammatory drugs effectiveness in colorectal distension (CRD)-induced visceral pain model.
Materials and Methods: Male Sprague–Dawley (250–300 g) rats were anesthetized with ketamine (50 mg/kg, intraperitoneally [i.p.]) and chlorpromazine (25 mg/kg, i.p.). Two bipolar Teflon-coated Ni/Cr wire electrodes (80-M diameter) were placed in the abdominal external oblique muscle for the recording of electromyography. Jugular vein catheter was placed for the administration of drugs. CRD method was applied to evaluate of visceral pain. All drugs (paracetamol, meloxicam, metamizole, and dexketoprofen) administered intravenously.
Results: Paracetamol 200, 400, and 600 mg/kg did not change the visceromotor response (VMR) when compare with the control group. Meloxicam 2 and 4 mg/kg showed no effect but at doses of 6 mg/kg meloxicam significantly ([51.9 ± 6.4%] [P < 0.001]) decreased VMR compared with the control group. Metamizole 200 mg/kg did not change responses but dose of 400 and 600 mg/kg metamizole reduced VMR. Dexketoprofen 2 and 4 mg/kg did not cause a change in VMR but 6 mg/kg dose significantly reduced response compared with the control group ([43.9 ± 3.9%, 36.8 ± 2.8%, 34.8 ± 2.5%, 42.1 ± 4.8%, 40.7 ± 3.5%, 36.4 ± 2.7%, and 26.1 ± 2.2%]; from 10 min to 70 min, respectively, [P < 0.05]).
Conclusion: Metamizole, dexketoprofen and meloxicam show antinociceptive effect with different duration of action on CRD-induced visceral pain model. This condition can be explained due to different chemical structures and different mechanisms which play a role in modulation of pain.
S Sirri Bilge
Department of Pharmacology, Medical Faculty, University of Ondokuz Mayis, Samsun
|How to cite this article:|
Baskin V, Bilge S S, Bozkurt A, Akyuz B, Agri AE, Guzel H, Ilkaya F. Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain.Indian J Pharmacol 2016;48:150-154
|How to cite this URL:|
Baskin V, Bilge S S, Bozkurt A, Akyuz B, Agri AE, Guzel H, Ilkaya F. Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain. Indian J Pharmacol [serial online] 2016 [cited 2022 Dec 7 ];48:150-154
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2016;volume=48;issue=2;spage=150;epage=154;aulast=Baskin;type=0