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Year : 2016  |  Volume : 48  |  Issue : 2  |  Page : 141--144

Anti-inflammatory effect of aqueous extracts of spent Pleurotus ostreatus substrates in mouse ears treated with 12-O-tetradecanoylphorbol-13-acetate

Nallely Rivero-Perez1, Maricela Ayala-Martinez1, Armando Zepeda-Bastida1, Marcos Meneses-Mayo2, Deyanira Ojeda-Ramirez1 
1 Academic Area of Veterinary Medicine, Autonomous University of Hidalgo Institute of Agricultural Sciences, Tulancingo, Hidalgo, Mexico
2 Department of Nutrition, Anahuac University Faculty of Health Sciences, Huixquilucan, Mexico

Correspondence Address:
Deyanira Ojeda-Ramirez
Academic Area of Veterinary Medicine, Autonomous University of Hidalgo Institute of Agricultural Sciences, Tulancingo, Hidalgo
Mexico

Aims: To evaluate the application of spent Pleurotus ostreatus substrates, enriched or not with medicinal herbs, as a source of anti-inflammatory compounds. Subjects and Methods: P. ostreatus was cultivated on five different substrates: Barley straw (BS) and BS combined 80:20 with medicinal herbs (Chenopodium ambrosioides L. [BS/CA], Rosmarinus officinalis L. [BS/RO], Litsea glaucescens Kunth [BS/LG], and Tagetes lucida Cav. [BS/TL]). The anti-inflammatory activity of aqueous extracts of spent mushroom substrates (SMSs) (4 mg/ear) was studied using an acute inflammation model in the mouse ear induced with 2.5 μg/ear 12-O-tetradecanoylphorbol13-acetate (TPA). Results: Groups treated with BS/CA, BS/RO, and BS/LG aqueous extracts exhibited the best anti-inflammatory activity (94.0% ± 5.5%, 92.9% ± 0.6%, and 90.4% ± 5.0% inhibition of auricular edema [IAO], respectively), and these effects were significantly different (P < 0.05) from that of the positive control indomethacin (0.5 mg/ear). BS/TL and BS were also able to reduce TPA-induced inflammation but to a lesser extent (70.0% ± 6.7% and 43.5% ± 6.6% IAO, respectively). Conclusions: Spent P. ostreatus substrate of BS possesses a slight anti-inflammatory effect. The addition of CA L. to mushroom substrate showed a slightly synergistic effect while RO L. had an additive effect. In addition, LG Kunth and TL Cav. enhanced the anti-inflammatory effect of SMS. However, to determine whether there is a synergistic or additive effect, it is necessary to determine the anti-inflammatory effect of each medicinal herb.


How to cite this article:
Rivero-Perez N, Ayala-Martinez M, Zepeda-Bastida A, Meneses-Mayo M, Ojeda-Ramirez D. Anti-inflammatory effect of aqueous extracts of spent Pleurotus ostreatus substrates in mouse ears treated with 12-O-tetradecanoylphorbol-13-acetate.Indian J Pharmacol 2016;48:141-144


How to cite this URL:
Rivero-Perez N, Ayala-Martinez M, Zepeda-Bastida A, Meneses-Mayo M, Ojeda-Ramirez D. Anti-inflammatory effect of aqueous extracts of spent Pleurotus ostreatus substrates in mouse ears treated with 12-O-tetradecanoylphorbol-13-acetate. Indian J Pharmacol [serial online] 2016 [cited 2021 Sep 28 ];48:141-144
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2016;volume=48;issue=2;spage=141;epage=144;aulast=Rivero-Perez;type=0