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Metabolic effects as a cause of myotoxic effects of fluoroquinolones
Thomas Metterlein1, Frank Schuster2, Martin Hager2, Norbert Roewer2, Martin Anetseder3
1 Department of Anesthesiology, University Hospital Regensburg, Regensburg, Germany
2 Department of Anesthesiology, Hospital Wuerzburg, Wuerzburg, Germany
3 Department of Anesthesiology, Achdorf Hospital, Landshut, Germany
Correspondence Address:
Dr. Thomas Metterlein
Department of Anesthesiology, University Hospital Regensburg, Regensburg
Germany
Objectives: To investigate if fluoroquinolones (FQs) influence skeletal muscle metabolism of healthy and malignant hyperthermia susceptible (MHS) pigs.
Materials and Methods: After approval from of the Animal Care Committee, 10 MHS pigs, and 6 MHS pigs were anesthetized with hemodynamic and systemic metabolic monitoring. Microdialysis catheters were placed intramuscularly. After equilibration, levofloxacin and ciprofloxacin were injected as a rapid bolus and continuous infusions. Lactate was measured in the dialysate and statistically analyzed was done (Wilcoxon-test; U-test;P < 0.05).
Results: There were no differences in age, weight, and baseline lactate levels between the groups. Both applications of levofloxacin- and ciprofloxacin-induced an increase of local lactate levels in healthy and MHS pigs. No difference between the two groups was observed.
Conclusion: FQs influence skeletal muscle metabolism. Myotoxic effects of FQs can, therefore, be explained by an influence on the cellular energy balance.
How to cite this article:
Metterlein T, Schuster F, Hager M, Roewer N, Anetseder M. Metabolic effects as a cause of myotoxic effects of fluoroquinolones.Indian J Pharmacol 2015;47:616-619
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How to cite this URL:
Metterlein T, Schuster F, Hager M, Roewer N, Anetseder M. Metabolic effects as a cause of myotoxic effects of fluoroquinolones. Indian J Pharmacol [serial online] 2015 [cited 2021 Oct 25 ];47:616-619
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=6;spage=616;epage=619;aulast=Metterlein;type=0 |
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