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Year : 2015  |  Volume : 47  |  Issue : 5  |  Page : 540--545

Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril

Daniel Chukwu Nwachukwu1, Eddy Ikemefuna Aneke2, Leonard Fidelis Obika3, Nkiru Zuada Nwachukwu4 
1 Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Enugu State, Nigeria
2 Department of Medicine, Enugu State University of Science and Technology, Enugu, Enugu State, Nigeria
3 Department of Physiology, School of Basic Medical Sciences, University of Benin, Benin City, Edo State, Nigeria
4 Department of Ophthalmology, University of Nigeria Teaching Hospital, Enugu, Enugu State, Nigeria

Correspondence Address:
Dr. Daniel Chukwu Nwachukwu
Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Enugu State
Nigeria

Objectives: The present study investigated the effects of aqueous extract of Hibiscus sabdariffa (HS) on the three basic components of renin-angiotensin-aldosterone system: Plasma renin, serum angiotensin-converting enzyme (ACE), and plasma aldosterone (PA) in mild to moderate essential hypertensive Nigerians and compared with that of lisinopril, an ACE inhibitor. Materials and Methods: A double-blind controlled randomized clinical study was used. Seventy-eight newly diagnosed but untreated mild to moderate hypertensive subjects attending Medical Outpatients Clinic of Enugu State University Teaching Hospital, Enugu were recruited for the study. Those in Group A received placebo (150 mg/kg/day), Group B were given lisinopril (10 mg once daily) while those in Group C received aqueous extract of HS (150 mg/kg/day). After 4 weeks of treatment, the levels of plasma renin, serum ACE, and PA were determined. Results: HS and lisinopril significantly (P < 0.001) reduced PA compared to placebo by 32.06% and 30.01%, respectively. Their effects on serum ACE and plasma renin activity (PRA) were not significant compared to placebo; they reduced ACE by 6.63% and 5.67% but increased plasma PRA by 2.77% and 5.36%, respectively. Conclusion: HS reduced serum ACE and PA in mild to moderate hypertensive Nigerians with equal efficacy as lisinopril. These actions are possibly due to the presence of anthocyanins in the extract.


How to cite this article:
Nwachukwu DC, Aneke EI, Obika LF, Nwachukwu NZ. Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril.Indian J Pharmacol 2015;47:540-545


How to cite this URL:
Nwachukwu DC, Aneke EI, Obika LF, Nwachukwu NZ. Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril. Indian J Pharmacol [serial online] 2015 [cited 2021 Oct 28 ];47:540-545
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=5;spage=540;epage=545;aulast=Nwachukwu;type=0