Indian Journal of Pharmacology Home 

RESEARCH ARTICLE
[View FULLTEXT] [Download PDF]
Year : 2015  |  Volume : 47  |  Issue : 4  |  Page : 409--413

Evaluation of skeletal muscle relaxant activity of aqueous extract of Nerium oleander flowers in Albino rats

Jayasree Tirumalasetti, Maulik Patel, Ubedulla Shaikh, K Harini, J Shankar 
 Department of Pharmacology, Mamata Medical College, Khammam, Telangana, India

Correspondence Address:
Dr. Jayasree Tirumalasetti
Department of Pharmacology, Mamata Medical College, Khammam, Telangana
India

Objectives: Nerium oleander is traditionally used in various diseases because of its medicinal properties. One of its uses is in musculoskeletal disorder. The aim of the study was to evaluate the skeletal muscle relaxant activity of the aqueous extract of Nerium oleander flowers (AENOF) in albino rats in comparison with diazepam. Materials and Methods: A total of 20 Swiss albino rats aged 6-7 weeks, of either sex, weighing about 100-150 g, were taken, and after acute toxicity studies two different doses were selected. The animals were divided into four different groups. The first group was kept as the control (normal saline), second as the standard (diazepam) and the remaining two groups as Test I and Test II, and given different doses of the AENOF. Skeletal muscle relaxant activity (motor coordination) on Rotarod and locomotor activity on photoactometer was performed. Statistical analysis was carried out by using analysis of variance, followed by Dunnett«SQ»s multiple comparison tests. Results: The result from the Actophotometer test and Rotarod test showed that the extract of AENOF significantly reduced (P < 0.05) the motor coordination of the tested animals. Conclusions: Our data indicates that AENOF possesses skeletal muscle relaxant activities.


How to cite this article:
Tirumalasetti J, Patel M, Shaikh U, Harini K, Shankar J. Evaluation of skeletal muscle relaxant activity of aqueous extract of Nerium oleander flowers in Albino rats.Indian J Pharmacol 2015;47:409-413


How to cite this URL:
Tirumalasetti J, Patel M, Shaikh U, Harini K, Shankar J. Evaluation of skeletal muscle relaxant activity of aqueous extract of Nerium oleander flowers in Albino rats. Indian J Pharmacol [serial online] 2015 [cited 2021 Apr 19 ];47:409-413
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=4;spage=409;epage=413;aulast=Tirumalasetti;type=0