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Anti-hyperbilirubinemic and wound healing activity of aqueous extract of Calotropis procera leaves in Wistar rats
Rupali Arun Patil, Aakash B Makwana
Department of Pharmacology, MGV's Pharmacy College, Nashik, Maharashtra, India
Correspondence Address:
Dr. Rupali Arun Patil
Department of Pharmacology, MGV«SQ»s Pharmacy College, Nashik, Maharashtra
India
Aims: The aim of this study was to evaluate the bilirubin lowering and wound healing property of aqueous extract of Calotropis procera (AECP) leaves in Wistar rats.
Materials and Methods: Albino Wistar rats of either sex were used for the study. Bilirubin lowering property of C. procera leaves was evaluated using phenylhydrazine and paracetamol as inducing agents followed by measuring the concentration of serum total bilirubin in hyperbilirubinemic rats. Wound healing property was evaluated using incision and excision models by measuring tensile breaking strength, percentage wound contractions, and epithelization days, respectively.
Statistical Analysis: Statistical comparison between groups in each experiment was done with one-way analysis of variance followed by Dunnett«SQ»s test.
Results: AECP showed a significant (P < 0.05) decrease in concentrations of serum total bilirubin in hyperbilirubinemic rats as well as significant (P < 0.05) increase in breaking strength and percentage wound contractions with decreased epithelization period when compared to control groups.
Conclusions: AECP showed significant bilirubin lowering and wound healing property in Wistar rats.
How to cite this article:
Patil RA, Makwana AB. Anti-hyperbilirubinemic and wound healing activity of aqueous extract of Calotropis procera leaves in Wistar rats.Indian J Pharmacol 2015;47:398-402
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How to cite this URL:
Patil RA, Makwana AB. Anti-hyperbilirubinemic and wound healing activity of aqueous extract of Calotropis procera leaves in Wistar rats. Indian J Pharmacol [serial online] 2015 [cited 2023 Mar 29 ];47:398-402
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=4;spage=398;epage=402;aulast=Patil;type=0 |
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