Single dose intravenous methyl prednisolone versus oral prednisolone in Bell俟Q製 palsy: A randomized controlled trial
Prithvi Giri, Ravindra Kumar Garg, Maneesh Kumar Singh, Rajesh Verma, Hardeep Singh Malhotra, Praveen Kumar Sharma
Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India
Objectives: Corticosteroids have been used in the treatment of Bell俟Q製 palsy and several other postinfectious neurological conditions. We hypothesized that administration of a single dose of intravenous (IV) methylprednisolone might be an effective alternative to oral prednisolone.
Materials and Methods: In this open label, randomized trial, patients with acute Bell俟Q製 palsy were randomized into two groups. One group received single dose (500 mg) of IV methylprednisolone while the other group received 10 days of oral prednisone. Outcome was assessed at 1 and 3 months with House-Brackmann scale.
Results: At 3 months, 93 (79.48%) patients had completely recovered. IV methylprednisolone and oral prednisolone groups had similar recovery rates (80% vs. 78.33%, P > 0.05). Patients with Grade 2 and 3 recovered completely. In patients with Grade 6, the recovery rate was 20%. A better outcome was observed if corticosteroids were administered within 3 days of onset of palsy.
Conclusion: Intravenous methylprednisolone and oral prednisolone showed equivalent benefit in patients with acute Bell俟Q製 palsy.
Ravindra Kumar Garg
Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh
|How to cite this article:|
Giri P, Garg RK, Singh MK, Verma R, Malhotra HS, Sharma PK. Single dose intravenous methyl prednisolone versus oral prednisolone in Bell's palsy: A randomized controlled trial.Indian J Pharmacol 2015;47:143-147
|How to cite this URL:|
Giri P, Garg RK, Singh MK, Verma R, Malhotra HS, Sharma PK. Single dose intravenous methyl prednisolone versus oral prednisolone in Bell's palsy: A randomized controlled trial. Indian J Pharmacol [serial online] 2015 [cited 2021 Jan 20 ];47:143-147
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=2;spage=143;epage=147;aulast=Giri;type=0