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Evaluation of anti-osteoarthritic activity of Vigna mungo in papain induced osteoarthritis model
Dhaval V Patel1, Mrunal Ghag Sawant2, Ginpreet Kaur1
1 Department of Pharmacology, SPP School of Pharmacy and Technology Management, Vile Parle (West), India
2 Department of Toxicology, Haffkine Institute, Mumbai, Maharashtra, India
Correspondence Address:
Dr. Ginpreet Kaur
Department of Pharmacology, SPP School of Pharmacy and Technology Management, Vile Parle (West)
India
Aim: This study was carried out to evaluate the effect of Vigna mungo hydroalcoholic extract (VMHA) by papain induced osteoarthritis (OA) in the rat model.
Materials and Methods: OA was induced by intra-articular injection of papain (4% w/v) along with cysteine (0.03 M) on day 1, 4 and 7 in rats and VMHA was administered orally in three doses (100, 200 and 400 mg/kg) after last papain injection. The anti-osteoarthritic activity was evaluated by measuring knee joint diameter, grip strength, locomotion activity and hanging time. Histopathological analysis and acute toxicity study were also performed.
Results: VMHA improved inflammatory condition with all the doses, but significant (P < 0.05) attenuation of inflammation was present only with 400 mg/kg dose. The grip strength, locomotion activity and hanging time were also significantly (P < 0.05) improved at dose level of 100 mg/kg however other two doses (200 mg/kg and 400 mg/kg) were not found to be effective. VMHA did not show any mortality or any toxic clinical signs after oral administration of 2 g/kg dose.
Conclusion: VMHA improved arthritic condition by significantly reducing pain and inflammation.
How to cite this article:
Patel DV, Sawant MG, Kaur G. Evaluation of anti-osteoarthritic activity of Vigna mungo in papain induced osteoarthritis model.Indian J Pharmacol 2015;47:59-64
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How to cite this URL:
Patel DV, Sawant MG, Kaur G. Evaluation of anti-osteoarthritic activity of Vigna mungo in papain induced osteoarthritis model. Indian J Pharmacol [serial online] 2015 [cited 2023 Jun 9 ];47:59-64
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=1;spage=59;epage=64;aulast=Patel;type=0 |
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