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Interaction of aqueous leaf extract of Aegle marmelos (L.) Corr. with cholinergic, serotonergic and adrenergic receptors: An ex vivo study
Sanjeev Kumar, Rakesh Kumar Mahaseth, Mukesh Tiwari, Ratika Sehgal, Preety Rajora, Rajani Mathur
Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, New Delhi, India
Correspondence Address:
Dr. Rajani Mathur
Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, New Delhi
India
Objectives: The aim was to study interaction of aqueous leaf extract of Aegle marmelos (AM) with cholinergic, serotonergic, and adrenergic receptor systems using appropriate rat tissues-ileum, fundus and tracheal chain, respectively.
Materials and Methods: Cumulative concentration-response curves (CRC) were constructed at various doses on each tissue for AM and respective standard agonist. The CRC was again plotted in presence and absence of respective standard antagonist to confirm the interaction of receptor system and AM.
Results: AM induced concentration-dependent contractions in isolated rat ileum (0.2-6.4 mg/ml) and fundus (0.2-3.2 mg/ml) that were inhibited significantly (P < 0.05) in the presence of atropine (10−7 M) and ketanserin (10−6 M), respectively. The relaxant effect, produced by AM (0.2 mg/ml) on carbachol (10−5 M) precontracted rat tracheal chain, was also inhibited significantly (P < 0.05) by propranolol (1 ng/ml).
Conclusion: It may be concluded that AM possesses agonistic activity on cholinergic, serotonergic and adrenergic receptors.
How to cite this article:
Kumar S, Mahaseth RK, Tiwari M, Sehgal R, Rajora P, Mathur R. Interaction of aqueous leaf extract of Aegle marmelos (L.) Corr. with cholinergic, serotonergic and adrenergic receptors: An ex vivo study.Indian J Pharmacol 2015;47:109-113
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How to cite this URL:
Kumar S, Mahaseth RK, Tiwari M, Sehgal R, Rajora P, Mathur R. Interaction of aqueous leaf extract of Aegle marmelos (L.) Corr. with cholinergic, serotonergic and adrenergic receptors: An ex vivo study. Indian J Pharmacol [serial online] 2015 [cited 2023 Jun 1 ];47:109-113
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=1;spage=109;epage=113;aulast=Kumar;type=0 |
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