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Year : 2014  |  Volume : 46  |  Issue : 4  |  Page : 378--385

The role of adenosine receptors and endogenous adenosine in citalopram-induced cardiovascular toxicity

Kubilay Oransay, Nil Hocaoglu, Mujgan Buyukdeligoz, Yesim Tuncok, Sule Kalkan 
 Department of Pharmacology, Dokuz Eylul University, School of Medicine, Inciralti, Izmir, Turkey

Correspondence Address:
Sule Kalkan
Department of Pharmacology, Dokuz Eylul University, School of Medicine, Inciralti, Izmir
Turkey

Aim: We investigated the role of adenosine in citalopram-induced cardiotoxicity. Materials and Methods: Protocol 1: Rats were randomized into four groups. Sodium cromoglycate was administered to rats. Citalopram was infused after the 5% dextrose, 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX; A 1 receptor antagonist), 8-(-3-chlorostyryl)-caffeine (CSC; A 2a receptor antagonist), or dimethyl sulfoxide (DMSO) administrations. Protocol 2: First group received 5% dextrose intraperitoneally 1 hour prior to citalopram. Other rats were pretreated with erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA; inhibitor of adenosine deaminase) and S-(4-Nitrobenzyl)-6-thioinosine (NBTI; inhibitor of facilitated adenosine transport). After pretreatment, group 2 received 5% dextrose and group 3 received citalopram. Adenosine concentrations, mean arterial pressure (MAP), heart rate (HR),  QRS duration and QT interval were evaluated. Results: In the dextrose group, citalopram infusion caused a significant decrease in MAP and HR and caused a significant prolongation in QRS and QT. DPCPX infusion significantly prevented the prolongation of the QT interval when compared to control. In the second protocol, citalopram infusion did not cause a significant change in plasma adenosine concentrations, but a significant increase observed in EHNA/NBTI groups. In EHNA/NBTI groups, citalopram-induced MAP and HR reductions, QRS and QT prolongations were more significant than the dextrose group. Conclusions: Citalopram may lead to QT prolongation by stimulating adenosine A 1 receptors without affecting the release of adenosine.


How to cite this article:
Oransay K, Hocaoglu N, Buyukdeligoz M, Tuncok Y, Kalkan S. The role of adenosine receptors and endogenous adenosine in citalopram-induced cardiovascular toxicity .Indian J Pharmacol 2014;46:378-385


How to cite this URL:
Oransay K, Hocaoglu N, Buyukdeligoz M, Tuncok Y, Kalkan S. The role of adenosine receptors and endogenous adenosine in citalopram-induced cardiovascular toxicity . Indian J Pharmacol [serial online] 2014 [cited 2021 Apr 23 ];46:378-385
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2014;volume=46;issue=4;spage=378;epage=385;aulast=Oransay;type=0