Indian Journal of Pharmacology Home 

RESEARCH ARTICLE
[View FULLTEXT] [Download PDF]
Year : 2014  |  Volume : 46  |  Issue : 3  |  Page : 316--321

Azadirachta indica attenuates cisplatin-induced neurotoxicity in rats

Ahmed Esmat Abdel Moneim 
 Departments of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt

Correspondence Address:
Ahmed Esmat Abdel Moneim
Departments of Zoology and Entomology, Faculty of Science, Helwan University, Cairo
Egypt

Objective: The objective of this study is to investigate the neuroprotective effects of Azadirachta indica leaves against cisplatin (CP)-induced neurotoxicity. Materials and Methods: Female Wistar rats were treated with vehicle (control); a single intraperitoneal 5 mg/kg CP (CP group); neem leaves (orally 500 mg/kg) for 5 and 10 days, N5 and N10 groups, respectively; neem leaves (500 mg/kg) for 5 days after CP injection, collagenous protein nitrogen (CPN) group; neem leaves (500 mg/kg) for 5 days before CP injection, noncollagenous protein group and neem leaves in a dose of 500 mg/kg for 5 days before and after CP injection, noncollagenous protein nitrogen group. Rats were sacrificed 5 days after CP injection to determine neural lipid peroxidation (LPO), nitric oxide (NO), and glutathione (GSH) levels. The neuronal antioxidant enzymes were evaluated in brain homogenates. Results: CP injection increased LPO, NO levels and decreased GSH level, whereas neem reversed these effects. Morphological brain damage and apoptosis induction were apparent in the CP group. In the CPN group, the histological damage and apoptosis induction caused by CP was improved, whereas morphological findings of neem before and after CP injection implied a well preserved brain tissue. No changes, in biochemical parameters were observed with neem treated groups. Conclusion: This study suggests that methanolic extract of neem leaves may be of therapeutic benefit when used with CP.


How to cite this article:
Abdel Moneim AE. Azadirachta indica attenuates cisplatin-induced neurotoxicity in rats .Indian J Pharmacol 2014;46:316-321


How to cite this URL:
Abdel Moneim AE. Azadirachta indica attenuates cisplatin-induced neurotoxicity in rats . Indian J Pharmacol [serial online] 2014 [cited 2021 Nov 28 ];46:316-321
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2014;volume=46;issue=3;spage=316;epage=321;aulast=Abdel;type=0