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Year : 2014  |  Volume : 46  |  Issue : 1  |  Page : 100--104

Anti-anxiety effect of a novel 5-HT 3 receptor antagonist N-(benzo[d]thiazol-2-yl)-3-ethoxyquinoxalin-2-carboxamide (6k) using battery tests for anxiety in mice

Yeshwant Vijay Kurhe, Mahesh Radhakrishnan, Devadoss Thangaraj, Deepali Gupta 
 Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan, India

Correspondence Address:
Yeshwant Vijay Kurhe
Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan
India

Objective: To investigate the anti-anxiety activity of DQ6kDQ, a novel 5-hydroxytryptamine type 3 (5-HT 3 ) receptor antagonist in in mice. Materials and Methods: Anti-anxiety activity of DQ6kDQ (1, 2, and 4 mg/kg, intraperitoneally (i.p.)) was evaluated in mice by behavioral tests such as elevated plus maze (EPM), open field test (OFT), light-dark box (L&D), and hole board test (HBT). Diazepam (2 mg/kg, i.p.) served as reference standard. Results: DQ6kDQ significantly (P < 0.05) increased the time and entries in open arm in EPM as compared to vehicle control group. Further, DQ6kDQ significantly (P < 0.05) increased the central and peripheral ambulation along with rearings and time in central area; whereas, reduced the fecal pellets in OFT as compared to vehicle control group. There was significant (P < 0.05) reduction in the latency to enter dark chamber; whereas, increased number of crossings and time in light chamber in L&D aversion test by treatment with DQ6kDQ as compared to vehicle control group. In HBT, DQ6kDQ significantly (P < 0.05) increased the number of head dipping and squares crossed; whereas, reduced the latency for first head dip and number of fecal pellets as compared to vehicle control group. Conclusion: A novel 5-HT 3 receptor antagonist has anti-anxiety action.


How to cite this article:
Kurhe YV, Radhakrishnan M, Thangaraj D, Gupta D. Anti-anxiety effect of a novel 5-HT 3 receptor antagonist N-(benzo[d]thiazol-2-yl)-3-ethoxyquinoxalin-2-carboxamide (6k) using battery tests for anxiety in mice.Indian J Pharmacol 2014;46:100-104


How to cite this URL:
Kurhe YV, Radhakrishnan M, Thangaraj D, Gupta D. Anti-anxiety effect of a novel 5-HT 3 receptor antagonist N-(benzo[d]thiazol-2-yl)-3-ethoxyquinoxalin-2-carboxamide (6k) using battery tests for anxiety in mice. Indian J Pharmacol [serial online] 2014 [cited 2021 Apr 19 ];46:100-104
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2014;volume=46;issue=1;spage=100;epage=104;aulast=Kurhe;type=0