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Year : 2013  |  Volume : 45  |  Issue : 5  |  Page : 474--478

Wound healing activity of Sida cordifolia Linn. in rats

Rajesh S Pawar1, Pradeep K Chaurasiya1, Harish Rajak2, Pradeep K Singour1, Fedelic Ashish Toppo1, Ankit Jain1 
1 Pharmacognosy and Phytochemistry Laboratory, Faculty of Pharmacy, VNS Group of Institutions, Neelbud, Bhopal, Madhya Pradesh, India
2 Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur, C.G., India

Correspondence Address:
Rajesh S Pawar
Pharmacognosy and Phytochemistry Laboratory, Faculty of Pharmacy, VNS Group of Institutions, Neelbud, Bhopal, Madhya Pradesh
India

Introduction: The present study provides a scientific evaluation for the wound healing potential of ethanolic (EtOH) extract of Sida cordifolia Linn. (SCL) plant. Materials and Methods: Excision, incision and burn wounds were inflicted upon three groups of six rats each. Group I was assigned as control (ointment base). Group II was treated with 10% EtOH extract ointment. Group III was treated with standard silver sulfadiazine (0.01%) cream. The parameters observed were percentage of wound contraction, epithelialization period, hydroxyproline content, tensile strength including histopathological studies. Result: It was noted that the effect produced by the ethanolic extract of SCL ointment showed significant (P < 0.01) healing in all wound models when compared with the control group. All parameters such as wound contraction, epithelialization period, hydroxyproline content, tensile strength and histopathological studies showed significant (P < 0.01) changes when compared with the control. Conclusion: The ethanolic extract ointment of SCL effectively stimulates wound contraction; increases tensile strength of excision, incision and burn wounds.


How to cite this article:
Pawar RS, Chaurasiya PK, Rajak H, Singour PK, Toppo FA, Jain A. Wound healing activity of Sida cordifolia Linn. in rats.Indian J Pharmacol 2013;45:474-478


How to cite this URL:
Pawar RS, Chaurasiya PK, Rajak H, Singour PK, Toppo FA, Jain A. Wound healing activity of Sida cordifolia Linn. in rats. Indian J Pharmacol [serial online] 2013 [cited 2021 Apr 20 ];45:474-478
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2013;volume=45;issue=5;spage=474;epage=478;aulast=Pawar;type=0