Evaluation of anti-inflammatory effect of statins in chronic periodontitis
Snophia Suresh1, Satya Narayana1, P Jayakumar1, Uma Sudhakar1, V Pramod2
1 Department of Periodontology, Thaimoogambigai Dental College and Hospital, Chennai, India
2 Department of Periodontology, New Horizon Dental College, Bilaspur, Chattisgarh, India
Objectives: Statins are the group of lipid-lowering drugs commonly used to control cardiovascular and cerebrovascular diseases. Statins have potential anti-inflammatory effect by blocking the intermediate metabolites of the mevalonate pathway. The objective of this study was to evaluate the anti-inflammatory effect of statin medication in chronic periodontitis patients.
Materials and Methods: Thirty patients of age group between 40 and 60 years were selected from the outpatient pool of Department of Periodontics, Thaimoogambigai Dental College and Hospital, Chennai. Thirty patients selected were grouped into two groups, Group-I consists of patients with generalized chronic periodontitis and on statin medication and Group-II consists of patients with generalized chronic periodontitis. Clinical parameters were recorded and gingival crevicular fluid (GCF) samples were analyzed for interleukin (IL)-1β using commercially available enzyme-linked immunosorbent assay.
Results: The mean GCF IL-1® levels in generalized chronic periodontitis patients who are on statin medication (Group-I) were lower than the generalized chronic periodontitis patients without statin medication (Group-II).
Conclusion: Reduction of GCF IL-1β levels in statin users indicate that statins have anti-inflammatory effect on periodontal disease.
Department of Periodontology, Thaimoogambigai Dental College and Hospital, Chennai
|How to cite this article:|
Suresh S, Narayana S, Jayakumar P, Sudhakar U, Pramod V. Evaluation of anti-inflammatory effect of statins in chronic periodontitis.Indian J Pharmacol 2013;45:391-394
|How to cite this URL:|
Suresh S, Narayana S, Jayakumar P, Sudhakar U, Pramod V. Evaluation of anti-inflammatory effect of statins in chronic periodontitis. Indian J Pharmacol [serial online] 2013 [cited 2023 May 31 ];45:391-394
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2013;volume=45;issue=4;spage=391;epage=394;aulast=Suresh;type=0