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Year : 2013  |  Volume : 45  |  Issue : 3  |  Page : 286--288

Chemopreventive effect of montelukast in n-nitroso n-methyl urea induced mammary carcinogenesis in female Sprague-Dawley rats

Manonmani Alvin Jose, Ramakrishna Amathi, Duraiswami Sathyamurthy, Balasubramanian Nandha Kumar 
 Department of Pharmacology, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamil Nadu, India

Correspondence Address:
Manonmani Alvin Jose
Department of Pharmacology, Swamy Vivekanandha College of Pharmacy, Tiruchengode, Tamil Nadu
India

Objective: The objective of the study was to evaluate the chemopreventive effect of montelukast sodium; selective reversible cysteinyl leukotriene D 4 -receptor antagonist in N-nitroso N-methyl urea (NMU) induced mammary carcinogenesis in virgin female Sprague-Dawley rats. Materials and Methods: Thirty rats were divided into five groups (normal control, disease control, montelukast1 mg/kg, montelukast10 mg/kg, tamoxifen10 mg/kg) of six animals each.The drug was administered in two doses,1 mg/kg,and 10 mg/kg orally and compared with the standard drug tamoxifen (10 mg/kg)p.o. Results: Montelukast sodium 1 mg/kg,10 mg/kg, and tamoxifen10 mg/kg decreased the tumor incidences by 50%,66.67%, and 83.33% and the total number of tumors in group by 41.67%, 58.33% and 91.67% respectively, when compared to the disease control. Montelukast sodium 1 mg/kg,10 mg/kg,and tamoxifen10 mg/kg decreased the average tumor burden by 86.41%,94.8% and 95.97%and average tumor volume by 89.52%, 95.84%, and 95.4%respectively, when compared to disease control group. Conclusion: The results revealed that montelukast sodium prevent the mammary carcinogenesis and confirms the role of cysteinyl leukotriene D 4 -receptor in mammary gland neoplasia.


How to cite this article:
Jose MA, Amathi R, Sathyamurthy D, Kumar BN. Chemopreventive effect of montelukast in n-nitroso n-methyl urea induced mammary carcinogenesis in female Sprague-Dawley rats.Indian J Pharmacol 2013;45:286-288


How to cite this URL:
Jose MA, Amathi R, Sathyamurthy D, Kumar BN. Chemopreventive effect of montelukast in n-nitroso n-methyl urea induced mammary carcinogenesis in female Sprague-Dawley rats. Indian J Pharmacol [serial online] 2013 [cited 2021 Sep 28 ];45:286-288
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2013;volume=45;issue=3;spage=286;epage=288;aulast=Jose;type=0