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Year : 2013  |  Volume : 45  |  Issue : 2  |  Page : 184--186

Anticlastogenic activity of flavonoid rich extract of Cassia auriculata Linn. on experimental animal

Supriya S Deshpande1, Shailesh M Kewatkar2, Vivek V Paithankar1 
1 Dr. Punjabrao Medical College, Amravati, India
2 Pinnacle Biomedical Research Institute, Bhopal, India

Correspondence Address:
Supriya S Deshpande
Dr. Punjabrao Medical College, Amravati
India

Objective: To determine antimutagenic activity of Cassia auriculata Linn. on chromosomal damage induced by cyclophosphamide (CP). Material and Methods: In the present investigation, four groups of six Swiss albino mice in each group were used. Excepting for the first group all the remaining groups were treated with CP (50 mg/kg). Mice of third and fourth group were treated with ethyl acetate extract of C. auriculata Linn. at 100 mg/kg and 200 mg/kg with CP. Metaphase of bone marrow cells of all animals were analyzed for qualitative and quantitative chromosomal aberrations. Break, fragment, deletion, Polyploidy, pulverized, ring and total aberration were observed. Results: Flavonoids rich extracts of root of C. auriculata Linn. provided significant protection (P < 0.05) against CP induced chromosomal aberration. Total chromosomal aberration was found to be 12.16 and 7.33% in 100 and 200 mg/kg of extract treated animals respectively. Conclusion: From the present study it can was observed that ethyl acetate extract of C. auriculata Linn possess significant anti-mutagenic potential against CP induced chromosomal aberration.


How to cite this article:
Deshpande SS, Kewatkar SM, Paithankar VV. Anticlastogenic activity of flavonoid rich extract of Cassia auriculata Linn. on experimental animal.Indian J Pharmacol 2013;45:184-186


How to cite this URL:
Deshpande SS, Kewatkar SM, Paithankar VV. Anticlastogenic activity of flavonoid rich extract of Cassia auriculata Linn. on experimental animal. Indian J Pharmacol [serial online] 2013 [cited 2021 Dec 1 ];45:184-186
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2013;volume=45;issue=2;spage=184;epage=186;aulast=Deshpande;type=0