Study of interaction of tramadol with amlodipine in mice
Hiral Modi, Bipa Mazumdar, Jagatkumar Bhatt
Department of Pharmacology, Medical College, Baroda, Gujarat, India
Objective: To study a possible interaction between tramadol, an opioid analgesic and amlodipine, a dihydropyridine calcium channel blocker with proposed antinociceptive property.
Materials and Methods: Albino mice of Haffkine strain were used for the study. The experiment was carried out using tail-flick method. Different doses of tramadol (50 mg/kg, 22.8 mg/kg and 10 mg/kg) were administered intraperitoneally to select the nonanalgesic dose. The animals were treated with different doses of amlodipine (2.5 mg/kg, 3.0 mg/kg, 3.5 mg/kg) to study its antinociceptive action. Combination of different doses of both the drugs were administered to study antinociceptive effect of the combination.
Results: Tramadol, showed dose dependent antinociception which persisted for entire two hours of the study period. Antinociceptive action was seen with amlodipine at a dose of 3.5 mg/kg. Different doses of amlodipine (2.5 mg/kg, 3.0 mg/kg) in combination with the nonanalgesic dose of tramadol (10 mg/kg) produced a significant enhancement of antinociceptive effect of tramadol. Combination of 3.5 mg/kg dose of amlodipine with nonanalgesic dose of tramadol (10 mg/kg) further enhances antinociceptive activity.
Conclusion: It is concluded that combination of amlodipine, a N - type calcium channel blocker, with tramadol produce significant enhancement of antinociceptive activity of tramadol.
Department of Pharmacology, Medical College, Baroda, Gujarat
|How to cite this article:|
Modi H, Mazumdar B, Bhatt J. Study of interaction of tramadol with amlodipine in mice.Indian J Pharmacol 2013;45:76-79
|How to cite this URL:|
Modi H, Mazumdar B, Bhatt J. Study of interaction of tramadol with amlodipine in mice. Indian J Pharmacol [serial online] 2013 [cited 2023 Jun 9 ];45:76-79
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2013;volume=45;issue=1;spage=76;epage=79;aulast=Modi;type=0