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Year : 2012  |  Volume : 44  |  Issue : 6  |  Page : 801--802

Zidovudine-induced nail pigmentation in a 12-year-old boy

Sanjeevani M Chawre1, Shraddha M Pore1, Manish B Nandeshwar1, Nausheen M Masood2 
1 Department of Pharmacology, Dr. V. M. Govt. Medical College and Shri Chhatrapati Shivaji Maharaj Sarvopchar Rugnalaya, Solapur, Maharashtra, India
2 Department of Skin VD, Dr. V. M. Govt. Medical College and Shri Chhatrapati Shivaji Maharaj Sarvopchar Rugnalaya, Solapur, Maharashtra, India

Correspondence Address:
Shraddha M Pore
Department of Pharmacology, Dr. V. M. Govt. Medical College and Shri Chhatrapati Shivaji Maharaj Sarvopchar Rugnalaya, Solapur, Maharashtra
India

Zidovudine is an important component of first-line antiretroviral treatment (ART) regimens used to manage pediatric HIV. Nail pigmentation with zidovudine is a well-documented occurrence in adults, especially dark-skinned individuals. But it has so far not been reported in children. Here, we report a pediatric case of zidovudine-induced nail pigmentation. A 12-year-old boy receiving ART with zidovudine, lamivudine, and nevirapine presented to dermatology OPD with complaint of diffuse bluish-brown discoloration of all fingernails. The pigmentation was noticed by the patient after 3 months of initiating zidovudine-based regimen. It first appeared in thumb nails, gradually involved all fingernails, and increased in intensity over time. Though harmless and reversible, psychological aspects of this noticeable side effect may hamper adherence to therapy and may lead to unnecessary investigations and treatment for misdiagnosis such as cyanosis or melanoma.


How to cite this article:
Chawre SM, Pore SM, Nandeshwar MB, Masood NM. Zidovudine-induced nail pigmentation in a 12-year-old boy.Indian J Pharmacol 2012;44:801-802


How to cite this URL:
Chawre SM, Pore SM, Nandeshwar MB, Masood NM. Zidovudine-induced nail pigmentation in a 12-year-old boy. Indian J Pharmacol [serial online] 2012 [cited 2021 Dec 2 ];44:801-802
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2012;volume=44;issue=6;spage=801;epage=802;aulast=Chawre;type=0