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Neuroprotective activity of Stereospermum suaveolens DC against 6-OHDA induced Parkinson俟Q製 disease model
MH Shalavadi1, VM Chandrashekhar1, SP Avinash1, C Sowmya1, A Ramkishan2
1 Department of Pharmacology and Research Centre, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Campus, Bagalkot, Karnataka, India
2 Assistant Drugs Controller (India), CDSCO, Subzonal Office, Airport, Ahmedabad - 380015, Gujarat, India
Correspondence Address:
V M Chandrashekhar
Department of Pharmacology and Research Centre, Hanagal Shri Kumareshwar College of Pharmacy, BVVS Campus, Bagalkot, Karnataka
India
Objectives: To evaluate the neuroprotective effect of Stereospermum suaveolens DC on 6-hydroxy dopamine induced Parkinson俟Q製 disease model.
Materials and Methods: The study was conducted on Sprague-Dawley rats where parkinson俟Q製 disease was induced by producing the striatal 6-hydroxy dopamine lesions. The test animals received methanolic extract of Stereospermum suaveolens at dose of 125, 250 and 500 mg/kg for 42 days. Behavioral assessment, spontaneous locomotor activity and muscular coordination were studied. Antioxidant levels, striatal infraction area were assessed and histopathological studies were carried out.
Results: The Stereospermum suaveolens DC methanolic extract showed significant dose dependent increase in behavioral activity, improved muscular coordination. Significant reduction of lipid peroxidation (LPO), increased antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT) and non-enzymatic activity of glutathione (GSH) and total thiol levels in extract treated groups was observed in test groups as compared to control group. Striatal infarction area was significantly reduced in extract treated groups as compared to control group.
Conclusion: The methanolic extract of Stereospermum suaveolens DC showed neuroprotective activity against 6-hydroxy dopamine induced Parkinson俟Q製 disease in rats.
How to cite this article:
Shalavadi M H, Chandrashekhar V M, Avinash S P, Sowmya C, Ramkishan A. Neuroprotective activity of Stereospermum suaveolens DC against 6-OHDA induced Parkinson's disease model.Indian J Pharmacol 2012;44:737-743
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How to cite this URL:
Shalavadi M H, Chandrashekhar V M, Avinash S P, Sowmya C, Ramkishan A. Neuroprotective activity of Stereospermum suaveolens DC against 6-OHDA induced Parkinson's disease model. Indian J Pharmacol [serial online] 2012 [cited 2023 Oct 2 ];44:737-743
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2012;volume=44;issue=6;spage=737;epage=743;aulast=Shalavadi;type=0 |
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