|
Screening of Ficus religiosa leaves fractions for analgesic and anti-inflammatory activities
Vishal Gulecha1, T Sivakumar3, Aman Upaganlawar2, Manoj Mahajan2, Chandrashekhar Upasani2
1 Department of Pharmacology, SNJB'S SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik;Department of Medicinal Chemistry, Nandha College of Pharmacy, Erode, Tamilnadu, India
2 Department of Pharmacology, SNJB'S SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik, India
Correspondence Address:
Vishal Gulecha
Department of Pharmacology, SNJB«SQ»S SSDJ College of Pharmacy, Neminagar, Chandwad, Nashik;Department of Medicinal Chemistry, Nandha College of Pharmacy, Erode, Tamilnadu
India
Objective : To evaluate the different fractions of dried leaves of Ficus religiosa Linn for analgesic and anti-inflammatory activity using different models of pain and inflammation
Materials and Methods : The analgesic activity of F. religiosa carried out using acetic acid-induced writhing in mice and tail flick test in rats. The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema and cotton pellet-granuloma formation in rats. Five different fractions (FRI, FRII, FRIII, FRIV and FRV) of F. religiosa at the dose level of 20 and 40 mg/kg, p.o were tested.
Results : The fraction FRI (40 mg/kg, p.o.) and FRIII (40 mg/kg, p.o) were found to be more effective (P<0.01) in preventing carrageenan induced rat paw edema, cotton pellet granuloma formation, and acetic acid induced writhing compared to the other fractions. FRI (20 mg/kg, p.o.) and FRIII (20 mg/kg, p.o.) were also found to be more effective in increasing latency period in tail flick method.
Conclusion : Out of five different fractions of F. religiosa leaves tested, FRI and FRIII possess potent analgesic and anti-inflammatory activities against different models of inflammation and pain.
How to cite this article:
Gulecha V, Sivakumar T, Upaganlawar A, Mahajan M, Upasani C. Screening of Ficus religiosa leaves fractions for analgesic and anti-inflammatory activities.Indian J Pharmacol 2011;43:662-666
|
How to cite this URL:
Gulecha V, Sivakumar T, Upaganlawar A, Mahajan M, Upasani C. Screening of Ficus religiosa leaves fractions for analgesic and anti-inflammatory activities. Indian J Pharmacol [serial online] 2011 [cited 2023 Jun 10 ];43:662-666
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2011;volume=43;issue=6;spage=662;epage=666;aulast=Gulecha;type=0 |
|
