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Year : 2011  |  Volume : 43  |  Issue : 2  |  Page : 105--112

Newer molecules in the treatment of schizophrenia: A clinical update

Abhishek Ghosh, Kaustav Chakraborty, Surendra Kumar Mattoo 
 Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India

Correspondence Address:
Surendra Kumar Mattoo
Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012
India

Schizophrenia is a heterogeneous psychiatric disorder in which multiple neurotransmitter systems have been implicated. Increased and decreased dopamine transmission in the subcortical meso-limbic and meso-cortical systems is closely linked to the źDQ╗positiveźDQ╗ and źDQ╗negativeźDQ╗ symptoms of schizophrenia, respectively. Important roles have also been found for serotonin and acetylcholine, both of which are closely linked to dopamine. An abnormality in glutamate functioning involving N-methyl-D-aspartic acid as well as other receptor subtypes may underlie the dopamine dysfunction observed in schizophrenia. Since the discovery of chlorpromazine in 1952, researchers have been developing new molecules targeting various neurotransmitter systems to maximize their efficacy and tolerability. The advancements in molecular genetics have opened up new horizons to manipulate the post-receptor protein cascade and gene expression. Although the magic-wand still eludes us, the newer molecules hold a lot of promise in this condition.


How to cite this article:
Ghosh A, Chakraborty K, Mattoo SK. Newer molecules in the treatment of schizophrenia: A clinical update.Indian J Pharmacol 2011;43:105-112


How to cite this URL:
Ghosh A, Chakraborty K, Mattoo SK. Newer molecules in the treatment of schizophrenia: A clinical update. Indian J Pharmacol [serial online] 2011 [cited 2021 May 12 ];43:105-112
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2011;volume=43;issue=2;spage=105;epage=112;aulast=Ghosh;type=0