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A comparative study on the efficacy, safety, and cost-effectiveness of bimatoprost/timolol and dorzolamide/timolol combinations in glaucoma patients
R Jothi1, AM Ismail2, R Senthamarai2, Siddhartha Pal2
1 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641 402, Tamilnadu, India
2 Department of Pharmacy Practice, Periyar College of Pharmaceutical Sciences for Girls, Trichirappalli-620 021, Tamilnadu, India
Correspondence Address:
Siddhartha Pal
Department of Pharmacy Practice, Periyar College of Pharmaceutical Sciences for Girls, Trichirappalli-620 021, Tamilnadu
India
Aim: This study was designed to compare the bimatoprost/timolol combination and dorzolamide/timolol combination in glaucoma for efficacy, safety, and cost-effectiveness in a local population of Trichy in the state of Tamilnadu.
Materials and Methods: Eight-week, randomized, parallel group, open-label study was conducted on 48 patients of open angle glaucoma or ocular hypertension. After initial clinical assessment and baseline investigations, bimatoprost/timolol combination (Group A) was prescribed to 22 patients (2 patients lost after initial assessment) and dorzolamide/timolol combination (Group B) to 24 patients. The patients were reviewed after second and eighth weeks for cure rate and adverse drug reaction monitoring.
Results: At the end of 8 weeks, the mean reduction in intraocular pressure from baseline was 13.04 mmHg (95% confidence interval (CI): 10.67-14.70) with bimatoprost/timolol combination once daily (P < 0.01) and 9.46 mmHg (95% CI: 7.47-10.5) with dorzolamide/timolol combination twice daily. Both the treatments were safe. Cost-effective range of bimatoprost/timolol combination was lower than that of dorzolamide/timolol combination.
Conclusion: The fixed combination of bimatoprost/timolol was slightly more effective than that of dorzolamide/timolol combination in reducing IOP, and both treatments were generally well tolerated. Bimatoprost/timolol combination was more cost-effective (cost-effective analysis) than dorzolamide/timolol combination.
How to cite this article:
Jothi R, Ismail A M, Senthamarai R, Pal S. A comparative study on the efficacy, safety, and cost-effectiveness of bimatoprost/timolol and dorzolamide/timolol combinations in glaucoma patients.Indian J Pharmacol 2010;42:362-365
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How to cite this URL:
Jothi R, Ismail A M, Senthamarai R, Pal S. A comparative study on the efficacy, safety, and cost-effectiveness of bimatoprost/timolol and dorzolamide/timolol combinations in glaucoma patients. Indian J Pharmacol [serial online] 2010 [cited 2023 Sep 26 ];42:362-365
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2010;volume=42;issue=6;spage=362;epage=365;aulast=Jothi;type=0 |
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