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Year : 2010  |  Volume : 42  |  Issue : 3  |  Page : 185--188

Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats

Vivek Srivastava1, A.H.M Viswanathaswamy1, Govind Mohan2 
1 Department of Pharmacology, KLE Society College of Pharmacy, Hubli, India
2 S.N. Medical College, Agra, India

Correspondence Address:
Vivek Srivastava
Department of Pharmacology, KLE Society College of Pharmacy, Hubli
India

Objectives : To study the ulcer protective property of sodium cromoglycate in pylorus-ligated rats and the biochemical role in ulcer protection by various biochemical tests. Materials and Methods : The ulcer protective effect of sodium cromoglycate was studied using a Pyloric Ligation Model using Wistar albino rats. The antiulcer effect of sodium cromoglycate 40 mg/kg b.w., i.p., was compared with the reference drug ranitidine 27 mg/kg b.w., i.p. The ulcer index was calculated and other biochemical parameters like free acidity, total acidity, pH, mucin, pepsin and volume of gastric juice were determined. Results : Pylorus ligation showed a significant (P < 0.01) reduction in gastric volume, free acidity, total acidity and ulcer index as compared to the control. Conclusion : Sodium cromoglycate has activity equipotent to ranitidine.


How to cite this article:
Srivastava V, Viswanathaswamy A, Mohan G. Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats.Indian J Pharmacol 2010;42:185-188


How to cite this URL:
Srivastava V, Viswanathaswamy A, Mohan G. Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats. Indian J Pharmacol [serial online] 2010 [cited 2022 Oct 2 ];42:185-188
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2010;volume=42;issue=3;spage=185;epage=188;aulast=Srivastava;type=0