Immunomodulatory activity of a Chinese herbal drug Yi Shen Juan Bi in adjuvant arthritis,Pathirage Kamal Perera1, Yunman Li1, Cheng Peng1, Weirong Fang1, Caifeng Han2: Indian Journal of Pharmacology

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Year : 2010 \| Volume : 42 \| Issue : 2 \| Page : 65--69

Immunomodulatory activity of a Chinese herbal drug Yi Shen Juan Bi in adjuvant arthritis

Pathirage Kamal Perera¹, Yunman Li¹, Cheng Peng¹, Weirong Fang¹, Caifeng Han²
¹ Department of Physiology and Pharmacology, China Pharmaceutical University, Mailbox 207 Tongjiaxiang 24, Nanjing, Jiangsu, 210009, People's Republic of China
² Jiangsu Chiatai Qingjiang Pharmaceutical Co., Ltd. Huaian Jiangsu, People's Republic of China

Correspondence Address:
Yunman Li
Department of Physiology and Pharmacology, China Pharmaceutical University, Mailbox 207 Tongjiaxiang 24, Nanjing, Jiangsu, 210009, People«SQ»s Republic of China

Objective: To investigate the immunomodulating mechanisms of a Chinese herbal medicine Yi Shen Juan Bi (YJB) in treatment of adjuvant arthritis (AA) in rats. Materials and Methods: Levels of serum tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β) were measured by the Enzyme-Linked Immunosorbent Assay (ELISA). Expression of TNF-α mRNA and IL-1β mRNA in synovial cells was measured with the semi-quantitative technique of reverse transcription-polymerase chain reaction (RT-PCR), while caspase-3 was examined by western blot analysis. Results: The administration of YJB significantly decreased the production of serum TNF-α and IL-1β. It also decreased significantly the TNF-α mRNA, IL-1β mRNA, and caspase-3 expression in synoviocytes. Conclusions: YJB produces the immunomodulatory effects by downregulating the over-activated cytokines, while it activates caspase-3, which is the key executioner of apoptosis in the immune system. This may be the one of the underlying mechanisms that explains how YJB treats the rheumatoid arthritis.

How to cite this article:
Perera PK, Li Y, Peng C, Fang W, Han C. Immunomodulatory activity of a Chinese herbal drug Yi Shen Juan Bi in adjuvant arthritis.Indian J Pharmacol 2010;42:65-69

How to cite this URL:
Perera PK, Li Y, Peng C, Fang W, Han C. Immunomodulatory activity of a Chinese herbal drug Yi Shen Juan Bi in adjuvant arthritis. Indian J Pharmacol [serial online] 2010 [cited 2023 Mar 30 ];42:65-69
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2010;volume=42;issue=2;spage=65;epage=69;aulast=Perera;type=0