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Year : 2010  |  Volume : 42  |  Issue : 1  |  Page : 53--54

A suspected case of carbimazole-associated torsades de pointes

Chiranjib Bagchi1, Dhurjati Prasad Sinha2, Santanu Kumar Tripathi1 
1 Department of Pharmacology, Burdwan Medical College, Burdwan, West Bengal 713104, India
2 Department of Cardiology, Burdwan Medical College, Burdwan, West Bengal 713104, India

Correspondence Address:
Chiranjib Bagchi
Department of Pharmacology, Burdwan Medical College, Burdwan, West Bengal 713104
India

Torsades de pointes (TdP) or polymorphic ventricular tachycardia owing to drug-induced QT prolongation is a common cause of withdrawal of marketed drugs and has caused increasing concern in the recent past. Carbimazole, the common antithyroid drug, is not a very well-known offender to cause QT prolongation and TdP. Only a few cases of carbimazole-induced TdP have been reported so far. We report a 53-year-old woman who was on tab. carbimazole (10 mg) twice daily for one month and who presented with respiratory distress, palpitation and syncope attack. Her surface electrocardiogram (ECG) was showing the evidence of TdP and subsequently hypokalemia was also detected. She received conservative management including potassium supplementation. However, QT prolongation persisted even after normalization of serum potassium level. Carbimazole was withdrawn and the patient was discharged as she remained stable and symptom free. This study highlights a possible association between carbimazole and TdP.


How to cite this article:
Bagchi C, Sinha DP, Tripathi SK. A suspected case of carbimazole-associated torsades de pointes.Indian J Pharmacol 2010;42:53-54


How to cite this URL:
Bagchi C, Sinha DP, Tripathi SK. A suspected case of carbimazole-associated torsades de pointes. Indian J Pharmacol [serial online] 2010 [cited 2022 Jul 2 ];42:53-54
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2010;volume=42;issue=1;spage=53;epage=54;aulast=Bagchi;type=0