Indian Journal of Pharmacology Home 

CORRESPONDENCE
[Download PDF]
Year : 2009  |  Volume : 41  |  Issue : 6  |  Page : 289-

Is cytochrome modulation the new frontier for decreasing the risk of cataract?

Jaykaran 
 Department of Pharmacology, Government Medical College, Surat - 395 001, Gujarat, India

Correspondence Address:
Jaykaran
Department of Pharmacology, Government Medical College, Surat - 395 001, Gujarat
India




How to cite this article:
Jaykaran. Is cytochrome modulation the new frontier for decreasing the risk of cataract?.Indian J Pharmacol 2009;41:289-289


How to cite this URL:
Jaykaran. Is cytochrome modulation the new frontier for decreasing the risk of cataract?. Indian J Pharmacol [serial online] 2009 [cited 2022 Nov 28 ];41:289-289
Available from: https://www.ijp-online.com/text.asp?2009/41/6/289/59931


Full Text

Sir,

I read the interesting article by Nair et al.,. [1] "Is cytochrome modulation the new frontier for decreasing the risk of cataract?," wherein:

1. The authors used "Pioglitazone" as a tool for enzyme induction and "Diltiazem" for enzyme inhibition. I believe that instead of pioglitazone some other agents could have been used as the enzyme-inducing capacity of pioglitazone is questionable.

Ishida et al. evaluated the relation between the therapeutic effects of troglitazone and pioglitazone in steroid-induced diabetes. They measured the urinary excretion of 6[Beta]-hydroxycortisol and the ratio of 6[Beta]-hydroxycortisol to the cortisol marker of CYP3A4 induction. There was a significant increase in 6[Beta]-hydroxycortisol with troglitazone but it remained unchanged with pioglitazone. [2]

In a similar clinical study, the authors investigated the 6b-hydroxycortisol/free cortisol urinary ratio as a specific marker of CYP3A4 induction. In this study, six healthy subjects received pioglitazone 45 mg once daily on day 1 and from day 3 to day 12. The 6b-hydroxycortisol/free cortisol ratio in the urine was evaluated on day 1 and day 12. The mean (±SD) 6b-hydroxycortisol/free cortisol ratios in day 1 urine samples and day 12 urine samples were 4.99 ± 1.92 and 5.11 ± 2.01, respectively, indicating no ratio difference between day 12 versus day 1 (P = 0.29).[3] These and some other studies suggest that pioglitazone either does not induce the hepatic CYP3A4 enzyme system or is a weak inducer. [4],[5]

2. The authors used ANOVA and the post hoc Tuckey for the analysis of data. Data are expressed as the percentage of total number of lenses affected. I believe that this data is nominal data and thus the "Chi-square test" could have been a better choice instead of ANOVA in this study.

References

1Nair KS, Patel KV, Gandhi TR. Is cytochrome modulation the new frontier for decreasing the risk of cataract? Indian J Pharmacol 2009;41:72-4.
2Ishida T, Hosokawa H, Murao K, Tada T, Taminato T, Taka- hara J. The effect of troglitazone and pioglitazone on urinary excretion of 6b-hydroxycortisol in steroid induced diabetes. Diabetes 2000;49:115-8.
3Ged C, Rouillon JM, Pichard L, Combalbert J, Bressot N, Bories P, et al. The increase in urinary excretion of 6b-hydroxycortisol as a marker of human hepatic cytochrome P450 IIIA induction. Br J Clin Pharmacol 1989;28:373-87.
4Nowak SN, Edwards DJ, Clarke A, Anderson GD, Jaber LA. Pioglitazone: effect on CYP3A4 activity. J Clin Pharmacol 2002;42:1299-302.
5Prueksaritanont T, Vega JM, Zhao J, Gagliano K, Kuznetsova O, Musser B, et al. Interactions between simvastatin and troglitazone or pioglitazone in healthy subjects. J Clin Pharmacol 2001;41:573-81.