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Year : 2009  |  Volume : 41  |  Issue : 2  |  Page : 72--74

Is cytochrome modulation the new frontier for decreasing the risk of cataract?

Kavitha S Nair, Kirti V Patel, Tejal R Gandhi 
 Department of Pharmacology, Anand Pharmacy College, Opp Town Hall, Anand - 388 001, Gujarat, India

Correspondence Address:
Kavitha S Nair
Department of Pharmacology, Anand Pharmacy College, Opp Town Hall, Anand - 388 001, Gujarat
India

Aim: The present study was designed to study the effect of cytochrome P450 (CYP) modulators on the occurrence of cataract using male Sprague-Dawley rats weighing 40:50 gm. Materials and Methods: Macroscopical examination of the lens isolated from rats pretreated with diltiazem (30 mg/kg; once daily; PO) showed delayed occurrence of cataract while pioglitazone (3.8 mg/kg; once daily; PO) pretreatment demonstrated an early cataract. Results and Conclusion: A delayed occurrence of cataract with diltiazem (CYP inhibitor) and an early onset of cataract with pioglitazone (CYP inducer) indicate that a cytochrome P450 mediated pathway may affect the initiation of cataract but not the maturation pattern.


How to cite this article:
Nair KS, Patel KV, Gandhi TR. Is cytochrome modulation the new frontier for decreasing the risk of cataract?.Indian J Pharmacol 2009;41:72-74


How to cite this URL:
Nair KS, Patel KV, Gandhi TR. Is cytochrome modulation the new frontier for decreasing the risk of cataract?. Indian J Pharmacol [serial online] 2009 [cited 2022 Dec 2 ];41:72-74
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2009;volume=41;issue=2;spage=72;epage=74;aulast=Nair;type=0