Indian Journal of Pharmacology Home 

REVIEW ARTICLE
[View FULLTEXT] [Download PDF]
Year : 2008  |  Volume : 40  |  Issue : 2  |  Page : 49--58

A review on plant-derived natural products and their analogs with anti-tumor activity

KK Dholwani1, AK Saluja1, AR Gupta2, DR Shah2 
1 A.R College of Pharmacy affiliated to Sardar Patel University, Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 120, India
2 Maliba Pharmacy College affiliated to Veer Narmad South Gujarat University, Gopal Vidyanagar, Tarsadi, Ta-Bardoli, Dist-Surat, Gujarat - 394 350, India

Correspondence Address:
K K Dholwani
A.R College of Pharmacy affiliated to Sardar Patel University, Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 120
India

Traditional medicines, including Chinese herbal formulations, can serve as the source of potential new drugs, and initial research focuses on the isolation of bioactive lead compound(s). The development of novel plant-derived natural products and their analogs for anticancer activity details efforts to synthesize new derivatives based on bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design - based modification. Also, the anticancer activity of certain natural products and their analogs can be enhanced by synthesizing new derivatives based on active pharmacophore models; drug resistance and solubility and metabolic limitations can be overcome by appropriate molecular modifications; and new biological properties or mechanisms of action can be added by combining other functional groups or molecules. Preclinical screening for in vitro human cell line panels and selected in vivo xenograft testing then identifies the most promising drug development targets.


How to cite this article:
Dholwani K K, Saluja A K, Gupta A R, Shah D R. A review on plant-derived natural products and their analogs with anti-tumor activity.Indian J Pharmacol 2008;40:49-58


How to cite this URL:
Dholwani K K, Saluja A K, Gupta A R, Shah D R. A review on plant-derived natural products and their analogs with anti-tumor activity. Indian J Pharmacol [serial online] 2008 [cited 2021 Sep 28 ];40:49-58
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2008;volume=40;issue=2;spage=49;epage=58;aulast=Dholwani;type=0