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Year : 2007  |  Volume : 39  |  Issue : 6  |  Page : 299--302

Serum glucose and triglyceride lowering activity of some novel glitazones against dexamethasone-induced hyperlipidemia and insulin resistance

BR Prashantha Kumar1, TK Praveen1, MJ Nanjan1, MD Karvekar2, B Suresh1 
1 TIFAC CORE JSS College of Pharmacy, Rocklands, Ootacamund - 643 001, Tamil Nadu, India
2 Government College of Pharmacy, P Kalingarao Road, Bangalore - 560 027, Karnataka, India

Correspondence Address:
M J Nanjan
TIFAC CORE JSS College of Pharmacy, Rocklands, Ootacamund - 643 001, Tamil Nadu
India

Objectives: To study the serum glucose and triglyceride lowering activity of some novel glitazones against dexamethasone-induced hyperlipidemia and insulin resistance in rats. Materials and Methods: Serum glucose and triglyceride lowering activity of the test compounds and a standard, rosiglitazone, was tested at a dose of 10 mg/kg p.o. against dexamethasone-induced hyperlipidemia and insulin resistance in Sprague-Dawley (SD) rats. On day 11 of treatment, blood was collected for the estimation of serum glucose and triglyceride levels. Results: All the 14 compounds and rosiglitazone significantly ( P < 0.05) decreased dexamethasone-induced elevation of serum glucose when compared to dexamethasone-alone-treated group. Among these compounds, compound 10 showed better antihyperglycemic activity than rosiglitazone. Compounds 7, 8 and 9 have shown significant ( P < 0.05) serum triglyceride lowering activity than did rosiglitazone. Out of the 14 compounds tested, only compounds 7, 8 and 9 have shown both serum glucose and triglyceride lowering activity. Conclusion: The present study indicates that some of the newer glitazones show significant glucose and triglyceride lowering activity. In comparison to rosiglitazone, these glitazones show comparable serum glucose lowering and better triglyceride lowering activity.


How to cite this article:
Prashantha Kumar B R, Praveen T K, Nanjan M J, Karvekar M D, Suresh B. Serum glucose and triglyceride lowering activity of some novel glitazones against dexamethasone-induced hyperlipidemia and insulin resistance.Indian J Pharmacol 2007;39:299-302


How to cite this URL:
Prashantha Kumar B R, Praveen T K, Nanjan M J, Karvekar M D, Suresh B. Serum glucose and triglyceride lowering activity of some novel glitazones against dexamethasone-induced hyperlipidemia and insulin resistance. Indian J Pharmacol [serial online] 2007 [cited 2021 Dec 5 ];39:299-302
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2007;volume=39;issue=6;spage=299;epage=302;aulast=Prashantha;type=0