Anticandidal activity of Azadirachta indica
AC Charmaine Lloyd, T Menon, K Umamaheshwari
Department of Microbiology,Dr. ALM Post Graduate Institute of Basic Medical Sciences,University of Madras,Taramani, Chennai-600 113, India
OBJECTIVE: To study the antifungal activity of 10 different extracts of seed kernels of Azadirachta indica A. Juss (Meliaceae) on Candida sps. isolated from immunocompromised patients.
MATERIALS AND METHODS: The extractants used were hexane, methanol, chloroform, water, petroleum ether, dichloromethane, acetone and absolute alcohol. The products of a successive extraction procedure involving hexane, chloroform and methanol were also tested for anticandidal activity. The minimum inhibitory concentration was tested by broth dilution method at concentrations ranging from 1 to 0.0625 mg/ml.
RESULTS: The ethanol extract of commercial neem seed oil, ethanol extract of neem seed kernels and the hexane extract showed best results. All strains were resistant to methanol: chloroform: water extracts and chloroform extracts of the successive extraction procedure.
CONCLUSION: The hexane and alcoholic extracts of neem seed seem to be promising anticandidal agents.
Department of Microbiology,Dr. ALM Post Graduate Institute of Basic Medical Sciences,University of Madras,Taramani, Chennai-600 113
|How to cite this article:|
Charmaine Lloyd A C, Menon T, Umamaheshwari K. Anticandidal activity of Azadirachta indica.Indian J Pharmacol 2005;37:386-389
|How to cite this URL:|
Charmaine Lloyd A C, Menon T, Umamaheshwari K. Anticandidal activity of Azadirachta indica. Indian J Pharmacol [serial online] 2005 [cited 2023 Mar 29 ];37:386-389
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2005;volume=37;issue=6;spage=386;epage=389;aulast=Charmaine;type=0