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Effect of Aloe vera on nitric oxide production by macrophages during inflammation
D Sarkar1, A Dutta2, M Das1, K Sarkar1, C Mandal2, M Chatterjee1
1 Department of Pharmacology, Dr. BC Roy Postgraduate Institute of Basic Medical Sciences, I.P.G.M.E.R., 244B Acharya JC Bose Road, Kolkata- 700 020, India
2 Department of Immunobiology, Indian Institute of Chemical Biology, Kolkata, India
Correspondence Address:
M Chatterjee
Department of Pharmacology, Dr. BC Roy Postgraduate Institute of Basic Medical Sciences, I.P.G.M.E.R., 244B Acharya JC Bose Road, Kolkata- 700 020
India
OBJECTIVE : To demonstrate the mechanism of action mediating the acute and chronic antiinflammatory activity of leafy exudate of Aloe vera (AVL) in animal models of inflammation.
MATERIALS AND METHODS : The acute antiinflammatory activity of AVL was evaluated using carrageenan and dextran as phlogistic agents while its chronic antiinflammatory effect was investigated in a complete Freund«SQ»s adjuvant-induced model of arthritis. The degree of inflammation in all models was measured plethysmographically. The effect of AVL on nitric oxide production in mouse peritoneal macrophages was measured by the Griess reagent.
RESULTS : AVL (25 mg/kg) significantly reduced carrageenan and dextran-induced pedal edema in rats by 61.9% and 61.7%, respectively. In the Freund«SQ»s adjuvant-induced model of chronic inflammation, AVL showed chronic antiinflammatory activity but failed to decrease the arthritic index indicating the absence of antiarthritic activity. AVL (10 µg/ml) caused a decrease in NO production in macrophages without causing toxicity.
CONCLUSION : AVL possesses acute and chronic antiinflammatory activity, which is partly mediated by reduced production of NO, which in turn prevents the release of inflammatory mediators.
How to cite this article:
Sarkar D, Dutta A, Das M, Sarkar K, Mandal C, Chatterjee M. Effect of Aloe vera on nitric oxide production by macrophages during inflammation.Indian J Pharmacol 2005;37:371-375
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How to cite this URL:
Sarkar D, Dutta A, Das M, Sarkar K, Mandal C, Chatterjee M. Effect of Aloe vera on nitric oxide production by macrophages during inflammation. Indian J Pharmacol [serial online] 2005 [cited 2023 Mar 29 ];37:371-375
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2005;volume=37;issue=6;spage=371;epage=375;aulast=Sarkar;type=0 |
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