«DQ»Quick Cycle«DQ» neoadjuvant chemotherapy in squamous cell carcinoma of cervix
A Taneja1, Shalini Rajaram2, S Agarwal3, KC Singh2, S Sahni4, N Goel2
1 Department of Obstetrics & Gynecology, Dayanand Medical College &Hospital, Ludhiana, Punjab, India
2 Department of Obstetrics and Gynecology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India
3 Department of Pathology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India
4 Specialty Ranbaxy, Mumbai, Maharashtra, India
Objective: To evaluate the efficacy and safety of a «SQ»Quick cycle«SQ» neoadjuvant chemotherapeutic regime in squamous cell carcinoma (SCC) of cervix and monitor the response to chemotherapy using Squamous Cell Carcinoma Antigen (SCC-Ag) as tumor marker.
Materials and Methods: Thirty patients with SCC of cervix (Stage I-IV) entered the study to receive three courses of multiagent neoadjuvant chemotherapy (vincristine, cisplatin and bleomycin) in a weekly regime. SCC-Ag was evaluated in these patients«SQ» pre and post-chemotherapy.
Results: Patients with stage IB2 had a complete response and two of seven patients with stage IIB became operable. The overall response rate was 47.8% and complete response rate was 8.7%. Decrease in tumor volume post-chemotherapy was significant (P<0.002). Toxicity including myelosuppression was minimal. A statistically significant decrease in SCC-Ag (stage II and III) was seen post-chemotherapy (P <0.04 and 0.005, respectively).
Conclusion: The weekly chemotherapeutic regime was found to be safe and effective and SCC-Ag is a useful tumor marker for monitoring response to chemotherapy.
B-704 Gitanjali Apartments, Vikas Marg Extension, Delhi-110 092
|How to cite this article:|
Taneja A, Rajaram S, Agarwal S, Singh K C, Sahni S, Goel N. "Quick Cycle" neoadjuvant chemotherapy in squamous cell carcinoma of cervix.Indian J Pharmacol 2005;37:320-324
|How to cite this URL:|
Taneja A, Rajaram S, Agarwal S, Singh K C, Sahni S, Goel N. "Quick Cycle" neoadjuvant chemotherapy in squamous cell carcinoma of cervix. Indian J Pharmacol [serial online] 2005 [cited 2023 Mar 24 ];37:320-324
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2005;volume=37;issue=5;spage=320;epage=324;aulast=Taneja;type=0