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Investigations of Sapindus trifoliatus in dopaminergic and serotonergic systems: Putative antimigraine mechanisms
DK Arulmozhi1, A Veeranjaneyulu2, SL Bodhankar4, SK Arora2
1 New Chemical Entity Research, Lupin Research Park, Village Nande, Taluk Mulshi, Pune-411 042 and Department of Pharmacology, Bharati Vidyapeeth, Poona College of Pharmacy, Pune-411 038, India
2 New Chemical Entity Research, Lupin Research Park, Village Nande, Taluk Mulshi, Pune-411 042, India
Correspondence Address:
A Veeranjaneyulu
New Chemical Entity Research, Lupin Research Park, Village Nande, Taluk Mulshi, Pune-411 042
India
OBJECTIVE: To evaluate the potential dopaminergic and serotonergic receptor-mediated modulatory effect of the aqueous extract of Sapindus trifoliatus [(ST), (family: Sapindaceae)], a traditional phytomedicine used in the treatment of hemicrania (migraine), using animal models and receptor assays.
MATERIALS AND METHODS: ST (at 20 and 100 mg/kg, i.p. doses) was evaluated for its effect on apomorphine-induced climbing behavior, 5-hydroxytryptophan (l-5-HTP)-induced serotonin syndrome, and MK-801-induced hyperactivity in mice. The radioligand binding studies for various receptors and enzymes were carried out (outsourced) using standard procedures at 250 µg/ml concentration of ST.
RESULTS: ST significantly inhibited the apomorphine-induced climbing behavior, the l-5-HTP-induced serotonin syndrome and MK-801-induced hyperactivity in mice. In the receptor radioligand binding studies, ST exhibited affinity towards dopamine D2, 5-HT2A receptors.
CONCLUSION: The results of the behavioral studies in mice indicate that ST modulated D2 and 5-HT2A receptor-mediated paradigms. The radioligand binding studies supported these observations, suggesting the possible involvement of dopaminergic and serotonergic mechanisms in the antimigraine activity of ST.
How to cite this article:
Arulmozhi D K, Veeranjaneyulu A, Bodhankar S L, Arora S K. Investigations of Sapindus trifoliatus in dopaminergic and serotonergic systems: Putative antimigraine mechanisms.Indian J Pharmacol 2005;37:120-125
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How to cite this URL:
Arulmozhi D K, Veeranjaneyulu A, Bodhankar S L, Arora S K. Investigations of Sapindus trifoliatus in dopaminergic and serotonergic systems: Putative antimigraine mechanisms. Indian J Pharmacol [serial online] 2005 [cited 2023 May 28 ];37:120-125
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2005;volume=37;issue=2;spage=120;epage=125;aulast=Arulmozhi;type=0 |
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