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Year : 2004  |  Volume : 36  |  Issue : 2  |  Page : 84--86

Comparison of the inhibitory effect of ATP-dependent K+ channel blockers glibenclamide and chlorpropamide, on diazoxide-induced relaxation of rat ileum

A Babaei1, J Mohiti2 
1 Departments of Pharmacology, Shahid Sadoughi University of Medical Science, Yazd, Iran
2 Departments of Biochemistry, Shahid Sadoughi University of Medical Science, Yazd, Iran

Correspondence Address:
A Babaei
Departments of Pharmacology, Shahid Sadoughi University of Medical Science, Yazd
Iran

Objective: This study was conducted to compare the potential inhibitory effect of ATP-dependent K+ channel blockers, glibenclamide and chlorpropamide on diazoxide-induced relaxation of isolated rat ileum. Material and Methods: The study was performed on rat ileum connected to an isotonic transducer and the contractions were recorded on one-channel MD2 recorder. In this study the relaxant effect of diazoxide on KCl-induced precontracted rat ileum, and its inhibition by different concentrations of glibenclamide and chlorpropamide were studied. Results: Diazoxide (10-5-10-3M) produced dose-dependent relaxation. EC50 for diazoxide-induced relaxation was 8 x 10-5M. Neither glibenclamide nor chlorpropamide had any effect on the resting tension of the rat ileum preparation. Both glibenclamide and chlorpropamide reversed diazoxide-induced relaxation. The pA2 values for glibenclamide and chlorpropamide reversal of diazoxide induced- relaxation were 6.3 and 5 respectively. Conclusion: The results confirm that the inhibitory effect of glibenclamide on diazoxide-induced relaxation in rat ileum is higher than that of chlorpropamide.


How to cite this article:
Babaei A, Mohiti J. Comparison of the inhibitory effect of ATP-dependent K+ channel blockers glibenclamide and chlorpropamide, on diazoxide-induced relaxation of rat ileum.Indian J Pharmacol 2004;36:84-86


How to cite this URL:
Babaei A, Mohiti J. Comparison of the inhibitory effect of ATP-dependent K+ channel blockers glibenclamide and chlorpropamide, on diazoxide-induced relaxation of rat ileum. Indian J Pharmacol [serial online] 2004 [cited 2021 Dec 9 ];36:84-86
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2004;volume=36;issue=2;spage=84;epage=86;aulast=Babaei;type=0