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Year : 2002  |  Volume : 34  |  Issue : 5  |  Page : 365--366

Effect of methanolic extract of Benincasa hispida against histamine and acetylcholine induced bronchospasm in guinea pigs

Kumar Anil1, P Ramu2 
1 
2 

Correspondence Address:
Kumar Anil


Objective: The effects of Bonny light crude oil on the smooth and skeletal muscles contraction and pain were investigated. Methods: Analgesic effect of Bonny light crude oil was tested in mice using acetic acid (0.75%)- induced writhing model. Its effects on histamine-, and Ach-induced smooth muscle contraction were studied in guinea pig ileum. The effects of crude oil on Ach-induced contraction of rat duodenum and frog rectus abdominis muscle were also studied. Results: The crude oil caused complete inhibition of histamine - induced smooth muscle contraction, while producing only a partial inhibition of the acetylcholine - induced contraction. It had no effects on the acetylcholine-induced skeletal muscle contraction, but showed good analgesic effect comparable to aspirin. Conclusion: The Bonny light crude oil possesses inhibitory action on smooth muscle contraction induced by histamine, and analgesic property.


How to cite this article:
Anil K, Ramu P. Effect of methanolic extract of Benincasa hispida against histamine and acetylcholine induced bronchospasm in guinea pigs.Indian J Pharmacol 2002;34:365-366


How to cite this URL:
Anil K, Ramu P. Effect of methanolic extract of Benincasa hispida against histamine and acetylcholine induced bronchospasm in guinea pigs. Indian J Pharmacol [serial online] 2002 [cited 2021 Jan 26 ];34:365-366
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2002;volume=34;issue=5;spage=365;epage=366;aulast=Anil;type=0