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Year : 2002  |  Volume : 34  |  Issue : 5  |  Page : 350--355

Intraventricular methotrexate: motor deficit in male Wistar rats

Madhyastha Sampath1, SN Somayaji2, K Nalini3, BS Nayak4, KL Bairy5 
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Madhyastha Sampath


Objectives: The effect of BR-16A (MentatR) on aluminium-induced cognitive deficits and cognition in aged rats was studied in a one-trial step-through passive avoidance task. Methods: Aluminium chloride (1000 mg/kg/day) was administered to wistar rats for 40 days to produce significant cognitive deficits (P<0.05). Aluminium-treated rats received BR-l 6A (100 mg/kg/day) for 20 days starting day 21. In a second experiment, aged wistar rats (12 months) received BR-16A (100 mg/kg/day) or vehicle for 20 days. Results: BR-16A significantly prolonged the shortened latency of step-through induced by aluminium administration [300 (214.17 - 300) vs 60.5(16 - 213); P<0.05] It also significantly improved retention of learning in aged rats [300(120.8 - 300) vs 37(27.5 - 189.5); P<0.01]. Conclusion: These results suggest that BR-16A improves learning and memory in aluminium-treated and aged rats.


How to cite this article:
Sampath M, Somayaji S N, Nalini K, Nayak B S, Bairy K L. Intraventricular methotrexate: motor deficit in male Wistar rats.Indian J Pharmacol 2002;34:350-355


How to cite this URL:
Sampath M, Somayaji S N, Nalini K, Nayak B S, Bairy K L. Intraventricular methotrexate: motor deficit in male Wistar rats. Indian J Pharmacol [serial online] 2002 [cited 2023 Jan 28 ];34:350-355
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2002;volume=34;issue=5;spage=350;epage=355;aulast=Sampath;type=0