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Year : 2002  |  Volume : 34  |  Issue : 5  |  Page : 311--320

Phytoestrogens in health and illness

RK Rishi 
 

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R K Rishi


Cycleanine, an alkaloidal extractive from the root bark of Synclisia scabridav, was screened for some peripheral and central effects in addition to acute toxicological investigation. The intraperitoneal LD50 in mice was established as 1010.5 mg/kg. In vivo studies using mice revealed that cycleanine significantly reduced spontaneous motor activity (SMA) in a dose related manner. There was synchronization of EEG and activation of EMG. In vitro studies using isolated rat uterus showed that cycleanine evoked concentration dependent contractions that were resistant to atropine but blocked by salbutamol. These results help to explain the rationale for the folkloric use of the plant in various CNS and peripheral disorders, and also implicate cycleanine as the putative active component.


How to cite this article:
Rishi R K. Phytoestrogens in health and illness.Indian J Pharmacol 2002;34:311-320


How to cite this URL:
Rishi R K. Phytoestrogens in health and illness. Indian J Pharmacol [serial online] 2002 [cited 2023 Feb 1 ];34:311-320
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2002;volume=34;issue=5;spage=311;epage=320;aulast=Rishi;type=0