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Year : 2002  |  Volume : 34  |  Issue : 4  |  Page : 294--295

Office of research integrity

Singh Jatinder 
 

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Singh Jatinder


Ethanol has been shown to contract isolated frog rectus abdominis in a dose-dependent manner and it has been suggested that acetylcholine (Ach) or Ach like neurotransmitter may be responsible for these contractions. To confirm it further, the present work was undertaken. Agents used in the study were hemicholinium, vecuronium and physostigmine. It was observed that hemicholinium (10-5M) inhibited ethanol induced contraction, suggesting action of ethanol through cholinergic mechanisms rather than a direct action. Vecuronium (10-5M) exhibited a non-competitive antagonism with ethanol, while physostigmine (10-5M) did not potentiate ethanol - induced contraction, suggesting that ethanol acts by release of Ach-like substance the nature of which needs to be determined


How to cite this article:
Jatinder S. Office of research integrity.Indian J Pharmacol 2002;34:294-295


How to cite this URL:
Jatinder S. Office of research integrity. Indian J Pharmacol [serial online] 2002 [cited 2021 Dec 5 ];34:294-295
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2002;volume=34;issue=4;spage=294;epage=295;aulast=Jatinder;type=0