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Year : 2002  |  Volume : 34  |  Issue : 4  |  Page : 256--259

Effect of oral melatonin on exercise-induced oxidant stress in healthy subjects

Kumar K Vijay1, MUR Naidu2 
1 
2 

Correspondence Address:
Kumar K Vijay


1. Dopamine produced a dose-dependent contraction of rat anococcygeus muscle. in the presence of sub-threshold dose of metoclopramide (2.8 x 1O-8 M), the responses to dopamina were potontiated. 2. Dopamineinduced contractions were competitively antagonized by haloperidol and phentolamine. Phentolamine induced inhibition of dopamine-receptors was partially uncovered by motociopramide. 3. Dopamine (1 X 10-10 M) inhibited there sponses to field stimulation which was prevented by metoclopramide. 4 . In the reserpinized anococcygeus muscle preparations the responses to dopamine were reduced significantly and metoclopramide failed to produce any potentiation of the responses. 5. The data presented suggest the presence of inhibitory presynaptic dopamino receptors in the rat anococcygeus muscle that are specifically antagonized by metoclopramide.


How to cite this article:
Vijay KK, Naidu M. Effect of oral melatonin on exercise-induced oxidant stress in healthy subjects.Indian J Pharmacol 2002;34:256-259


How to cite this URL:
Vijay KK, Naidu M. Effect of oral melatonin on exercise-induced oxidant stress in healthy subjects. Indian J Pharmacol [serial online] 2002 [cited 2021 Nov 28 ];34:256-259
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2002;volume=34;issue=4;spage=256;epage=259;aulast=Vijay;type=0