EDUCATIONAL FORUM |
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| Year : 2002 | Volume
: 34
| Issue : 2 | Page : 86--89 |
Genotoxicity testing, a regulatory requirement for drug discovery and development: Impact of ICH guidelines
Rao P Rama1, CL Kaul2, GB Jena3
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Correspondence Address:
Rao P Rama
1. In the present study it has been shown that acetylsalicylic acid (ASA) produces hemolysis of both normal and G-6-PD deficient erythrocytes.
2. The degree of hemolysis is almost the same in both the erythrocytes.
3. Acetylation and peroxidation of membrane lipid do not appear to be necessary for the hemolytic effect of ASA.
4. Severe membrane damage as evident from the liberation of phospholipids and sterols appears to be the mechanism by which ASA produces hemolysis.
How to cite this article:
Rama RP, Kaul C L, Jena G B. Genotoxicity testing, a regulatory requirement for drug discovery and development: Impact of ICH guidelines.Indian J Pharmacol 2002;34:86-89
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How to cite this URL:
Rama RP, Kaul C L, Jena G B. Genotoxicity testing, a regulatory requirement for drug discovery and development: Impact of ICH guidelines. Indian J Pharmacol [serial online] 2002 [cited 2023 Jun 8 ];34:86-89
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2002;volume=34;issue=2;spage=86;epage=89;aulast=Rama;type=0 |
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