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Year : 2001  |  Volume : 33  |  Issue : 6  |  Page : 425--430

Effect of E.coli endotoxin induced fever on the pharmacokinetics and dosage regimen of cefuroxime in calves

RK Chaudhary1, AK Srivastava2, S Rampal3 
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2 
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Correspondence Address:
R K Chaudhary


1. The biochemical and haematological effects of tolmetin (a pyrole acetic acid derivative), on blood sugar,«SQ» serum cholesterol, serum uric acid, blood count, coagulation time, plasma fibrinogen content and euglobin clot lysis time (ELT) were studied in albino rabbits 2. Tolmetin (10 mg/kg), (P.O.) produced marked and significant hypoglycaemic, hypocholesterolaemic and hypouricaemic effects which started after one hour with a peak effect at two hours without complete recovery even upto four hours. 3. It decreased coagulation time and platelet count but increased plasma fibrinogen level and ELT.


How to cite this article:
Chaudhary R K, Srivastava A K, Rampal S. Effect of E.coli endotoxin induced fever on the pharmacokinetics and dosage regimen of cefuroxime in calves.Indian J Pharmacol 2001;33:425-430


How to cite this URL:
Chaudhary R K, Srivastava A K, Rampal S. Effect of E.coli endotoxin induced fever on the pharmacokinetics and dosage regimen of cefuroxime in calves. Indian J Pharmacol [serial online] 2001 [cited 2022 Aug 10 ];33:425-430
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2001;volume=33;issue=6;spage=425;epage=430;aulast=Chaudhary;type=0