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Year : 2000  |  Volume : 32  |  Issue : 6  |  Page : 381--383

Investigation of the biochemical evidence for the antiulcerogenic activity of Synclisia scabrida

E Obi1, JK Emeh2, OE Orisakwe3, OJ Afonne4, NA Ilondu5, PU Agbasi6 
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Correspondence Address:
E Obi


Objective: The antiulcerogenic activity of flavonoid (A) and alkaloid (B) fractions of the S. scabrida and their effect on alkaline phosphatase activity were studied. Methods: The ethanol extract of S. scabrida was subjected to a column and preparative thin layer chromatography to obtain partially pure fractions of A and B which were subjected to antiulcerogenic screening and effects on alkaline phosphatase activity using aspirin and 0.6N NaOH ulcer models. Results: The results showed that fractions A and B significantly (P<0.05) reduced both the ulcer index and alkaline phosphatase activity when compared with aspirin or 0.6N NaOH only. Conclusion: This study seems to implicate alkaline phosphatase as a biochemical evidence of the antiulceroragenic activity of S. scabrida.


How to cite this article:
Obi E, Emeh J K, Orisakwe O E, Afonne O J, Ilondu N A, Agbasi P U. Investigation of the biochemical evidence for the antiulcerogenic activity of Synclisia scabrida.Indian J Pharmacol 2000;32:381-383


How to cite this URL:
Obi E, Emeh J K, Orisakwe O E, Afonne O J, Ilondu N A, Agbasi P U. Investigation of the biochemical evidence for the antiulcerogenic activity of Synclisia scabrida. Indian J Pharmacol [serial online] 2000 [cited 2022 Oct 7 ];32:381-383
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2000;volume=32;issue=6;spage=381;epage=383;aulast=Obi;type=0